Günaj Rakipovski et al. BTS 2018;3:

Slides:

Advertisements

Similar presentations

Supplementary Table 1. Fatty acid composition of diets (expressed as % of total FA) 18:1 18:2 20:5 22:6 Total Total 12:0 14:0 16:0 16:1 18:0 (n-9) (n-6)

Advertisements

Supplemental Figure 1 A No. at risk T T T

P449. p450 Figure 15-1 p451 Figure 15-2 p453 Figure 15-2a p453.

14.5L/9.5DTime7:00- 9:00 9:00- 11:00 11:00- 15:00 15:00- 17:00 17:00- 19:00 19:00- 21:00 21:00- 23:00 23:00- 5:00 5:00- 7:00 Temperature

Complex 1 Complex 2 Complex 3

A B C Relative liver PPARa mRNA expression

Figure S2 A B Log2 Fold Change (+/- cAMP) Transcriptome (9hr)

Daniel J. Lenihan et al. BTS 2016;1:

NRSF regulates expression of endogenous ANP, BNP and α‐skeletal actin in ventricular myocytes. NRSF regulates expression of endogenous ANP, BNP and α‐skeletal.

Volume 15, Issue 1, Pages (January 2012)

Type 17 immunity is increased in STAT1−/− mice.

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Alignment of distal NOS2 promoters from cattle, human, and sheep, and the Bov-A2 element. Alignment of distal NOS2 promoters from cattle, human, and sheep,

Vesna Nikolova-Krstevski et al. BTS 2017;2:

Everolimus Inhibits SMC Proliferation Through Transcriptional Repression of Telomerase (A) Cell proliferation assay in primary murine vascular smooth muscle.

Rachel Truitt et al. BTS 2018;3:

Nikole J. Byrne et al. BTS 2017;j.jacbts

Helena M. Viola et al. BTS 2018;3:

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

NCoR1 controls basal expression of T3-target genes.

Everolimus Silences E2F Target Genes Through TERT-Dependent Epigenetic Histone Modification (A) Western blotting for MCM7 in WT and TERTtg mSMC treated.

Chapter 6 Transcription of Genes

Dandan Wang et al. BTS 2018;3: Cardiomyocyte-Specific Knock-In miR-24 Ameliorates Ischemia/Reperfusion Injury (A) Quantitative polymerase chain.

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Rachel Truitt et al. BTS 2018;3:

Mohamed A. Saleh et al. BTS 2016;1:

Validation of RNA transcription profile differential expression using real-time quantitative PCR. Relative gene expression in cases compared with controls.

Hironori Hara et al. BTS 2018;3:

Combination extract inhibits immune responses in vivo.

Sven Y. Surikow et al. BTS 2018;3:

Sven Y. Surikow et al. BTS 2018;3:

Romain Gallet et al. BTS 2016;1:14-28

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

Prachi Umbarkar et al. BTS 2019;j.jacbts

Hironori Hara et al. BTS 2018;3:

Blimp-1 expression is enhanced in both si-tolerant T cells and CD3/CD155-ligated T cells. Blimp-1 expression is enhanced in both si-tolerant T cells and.

Volume 7, Issue 6, Pages (June 2008)

UMOD and ACSM2A expressions correlate with renal function.

MAGs and testes transcript expression levels in the An. gambiae complex. MAGs and testes transcript expression levels in the An. gambiae complex. (A) Percentage.

Reduced FOXO1 expression in GC B cells from mice lacking regulatory CD4+ T cell–derived IL-10. Reduced FOXO1 expression in GC B cells from mice lacking.

Attenuated salicylic-acid-induced defense response in bt4 mutants.

Nikole J. Byrne et al. BTS 2017;j.jacbts

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

Mimic treatment induces eWAT inflammation and hepatic steatosis.

Diabetic FXR KO kidney showed increased lipid accumulation.

Distribution plot of the differentially expressed genes.

BTG2 regulates gluconeogenic gene expression in diabetic mouse models

Benjamini & Hochberg-corrected p < 0.05 Bonferroni-corrected

Nrf2−/− mice had higher TGF-β1 transcription and FN expression.

Transgenic restoration of long-chain n-3 PUFA protects against obesity-linked insulin resistance and glucose intolerance. Transgenic restoration of long-chain.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

OTU and family-level changes in murine gut as a result of acarbose feeding on a high-starch diet. OTU and family-level changes in murine gut as a result.

Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

Fig. 5 Transcriptional changes in dKO mice after HFD regimen.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Ju Youn Beak et al. BTS 2017;2:39-53

Genes that Respond to H2O2 Are Also Evoked Under Light in Arabidopsis

Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell.

Fig. 3 Transcriptional changes in dKO mice.

Volume 14, Issue 9, Pages (March 2016)

Volume 25, Issue 13, Pages e4 (December 2018)

Michael A. Makara et al. BTS 2018;3:

Figure 3. Immunohistochemistry assay for Mfn2 in each group

Graphical representation of the conditional model 2

MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.

Host gene expression changes following exposure to the microbiota.

FGFR2 amplification in primary human gastric tumors predicts for response to NVP-BGJ398. FGFR2 amplification in primary human gastric tumors predicts for.

Presentation transcript:

Günaj Rakipovski et al. BTS 2018;3:844-857 Semaglutide Lowered TG and Prevented WD-Induced Transcriptional Changes in Liver of LDLr−/− Mice (A) WD-induced increases of liver triglycerides were dose-dependently reduced by semaglutide: $$p = 0.0017, **p = 0.0045, ****p <0.0001 versus vehicle WD. (B) Semaglutide partially prevented WD induced increases in collagen gene expression: Benjamini-Hochberg-corrected p values: **p < 0.01; *p < 0.05 versus vehicle, WD. (C) Graphic representation of relative gene expression changes by WD and semaglutide compared to vehicle, chow. Benjamini-Hochberg-corrected p values: ****p < 0.0001, ***p < 0.001, **p < 0.01; *p < 0.05 versus vehicle, WD. Uncorrected and Benjamini-Hochberg-corrected p values for Figures 5B and 5C can be found in Supplemental Table S4. TG = triglyceride. Günaj Rakipovski et al. BTS 2018;3:844-857 2018 The Authors