Mucormycete Infiltration in the Cardiac Conduction System

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Mucormycete Infiltration in the Cardiac Conduction System Takashi Nawata, MD, Makoto Kubo, MD, PhD, Shigeki Kobayashi, MD, PhD, Narumi Nakada, MD, Masaki Maeda, MD, PhD, Dan Cui, MD, PhD, Tokuhiro Kimura, MD, PhD, Eiji Ikeda, MD, PhD, Masafumi Yano, MD, PhD Canadian Journal of Cardiology Volume 34, Issue 1, Pages 92.e9-92.e10 (January 2018) DOI: 10.1016/j.cjca.2017.10.002 Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 1 (A) Short-axis section of both ventricles with reddish nodules in the myocardium (arrows). (B) Low-power view of the histologic section of the upper ventricular septum with a nodular lesion (arrows) approximately 5 mm in diameter near the conduction system. (C and D) The nodular lesion in B contacted the proximal left bundle branch (arrowheads) and (D) demonstrated myocardial necrosis and neutrophil infiltration. (E) Grocott methenamine silver stain revealed hyphae of mucormycetes in the blood vessels (arrow) and heart muscles in the lesion. Scale bars: (B) 5 mm; (C) 500 μm; (D) 100 μm; (E) 50 μm. Stains: (B, C) azan stain; (D) hematoxylin-eosin stain; (E) Grocott methenamine silver stain. Canadian Journal of Cardiology 2018 34, 92.e9-92.e10DOI: (10.1016/j.cjca.2017.10.002) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions