Genetics of Blood Pressure Regulation: Possible Paths in the Labyrinth Luisa Foco, Cristian Pattaro  American Journal of Kidney Diseases  Volume 74, Issue 3, Pages 421-424 (September 2019) DOI: 10.1053/j.ajkd.2019.05.001 Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 (A) The MTHFR-CLCN6-NPPA-NPPB gene cluster, with indication of gene location and D′ linkage disequilibrium statistic (generated with Ensembl genome browser release 95; based on 499 single-nucleotide polymorphisms from the CEU panel of the 1000 Genomes phase 3 data set: https://www.ensembl.org/Homo_sapiens/Location/View?db=core;mr=1:11729843-11863539;pop1=373514;r=1:11700000-11900000). (B) CLCN6 localization in the kidney. Immunohistochemistry shows medium signal intensity in glomerulus and strong signal intensity in distal tubules. Pattern in proximal tubules is speckled and weaker. Image credit: Human Protein Atlas version 18.1. Shown is a portion of a slide of normal tissue from a male; the full image is available at https://www.proteinatlas.org/ENSG00000011021-CLCN6/tissue/kidney#imid_8822923. (C) Kidney-related genes that are likely to be involved in blood pressure regulation. American Journal of Kidney Diseases 2019 74, 421-424DOI: (10.1053/j.ajkd.2019.05.001) Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions