Fig. 6 Pharmacologic alterations of β-AR signaling regulate cardiomyocyte abscission and endowment. Pharmacologic alterations of β-AR signaling regulate.

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Fig. 6 Pharmacologic alterations of β-AR signaling regulate cardiomyocyte abscission and endowment. Pharmacologic alterations of β-AR signaling regulate cardiomyocyte abscission and endowment. (A) Ect2 mRNA expression in cultured NRVMs treated with Fsk (n = 5 cardiomyocyte isolations). (B) Immunostaining and quantification of multinucleated cardiomyocytes after Fsk administration in vivo (1 μg/g body, one intraperitoneal injection per day in newborn mice, n = 6 hearts per group). (C) Immunostaining and quantification of multinucleated cardiomyocytes (PBS: n = 4, prop: n = 3 hearts for P4; n = 4 hearts per group for P8) and (D) total number of cardiomyocytes (quantified by counting fixation-digested hearts; PBS: n = 7, prop: n = 6 hearts for P4; n = 4 hearts per group for P8) after propranolol administration (prop, 10 μg/g body, two intraperitoneal injections per day in newborn mice). (E) Immunostaining and quantification of cell cycle entry (n = 5 hearts per group for P8) and (F) M phase activity (n = 4 hearts per group for P8). (G) Immunostaining and quantification of multinucleated cardiomyocytes and (H) total number of cardiomyocytes (quantified by counting fixation-digested hearts) after alprenolol administration (alp, 10 μg/g body, two intraperitoneal injections per day in newborn mice, n = 6 hearts per group). Scale bars, 20 μm. Statistical significance was tested with Student’s t test (A, E, and F) and two-way ANOVA with Bonferroni’s multiple comparisons (B to D, G, and H). Honghai Liu et al., Sci Transl Med 2019;11:eaaw6419 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works