Effect of acyclovir on bronchoconstriction and urinary leukotriene E4 excretion in aspirin- induced asthma Satoshi Yoshida, MD, FCCPa,b, Hideo Sakamoto,

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Presentation transcript:

Effect of acyclovir on bronchoconstriction and urinary leukotriene E4 excretion in aspirin- induced asthma Satoshi Yoshida, MD, FCCPa,b, Hideo Sakamoto, PhD, FACBa, Yoko Yamawaki, MS, RNa, Tatsuhiro Shoji, MD, FACGb, Kazuhito Akahori, PharmD, FASCPb, Kazuya Onuma, MDb, Hiroshi Nakagawa, BScb, Hiroshi Hasegawa b, Hideaki Amayasu, MDb,c Journal of Allergy and Clinical Immunology Volume 102, Issue 6, Pages 909-914 (December 1998) DOI: 10.1016/S0091-6749(98)70327-6 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Individual results of PC20 sulpyrine at baseline period and after acyclovir. Both results are shown in mean with bar indicating SD. All PD20 values were logarithmically transformed before analysis, and summary statistics were expressed as mean ± SD. Journal of Allergy and Clinical Immunology 1998 102, 909-914DOI: (10.1016/S0091-6749(98)70327-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Mean urinary LTE4 before and during the observation period after placebo (open bars) or acyclovir (filled bars) . *P < .05. N.S., not significant. Journal of Allergy and Clinical Immunology 1998 102, 909-914DOI: (10.1016/S0091-6749(98)70327-6) Copyright © 1998 Mosby, Inc. Terms and Conditions