Fig. 3 Social transfer occurs via alcohol withdrawal–specific olfactory cues, and this state leads to chemical and thermal hyperalgesia. Social transfer.

Slides:

Advertisements

Similar presentations

Activation of Src Family Kinases in Spinal Microglia Contributes to Formalin-Induced Persistent Pain State Through p38 Pathway Yong-Hui Tan, Kai Li,

Advertisements

Mast cell activation contributes to sickle cell pathobiology and pain in mice by Lucile Vincent, Derek Vang, Julia Nguyen, Mihir Gupta, Kathryn Luk, Marna.

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat D.R. Sagar, L. Nwosu, D.A. Walsh,

Repeated administration of RGFP-966 improves short-term recognition and spatial memory in 3xTg-AD mice. Repeated administration of RGFP-966 improves short-term.

O. Moriarty, L. Harrington, S. Beggs, S.M. Walker

Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model Emerson Krock, Magali Millecamps,

Volume 23, Issue 23, Pages (December 2013)

AG-221 induces the differentiation of IDH2R140Q blasts along myeloid lineages in primary human AML xenograft models. AG-221 induces the differentiation.

Volume 128, Issue 7, Pages (June 2005)

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Levels of cytokines and chemokines in TPL-treated (from ED2) and control (H2O) mice at midgestation (ED10). Levels of cytokines and chemokines in TPL-treated.

Course of P. chabaudi AS infection and pregnancy outcome in ad libitum orally delivered TPL treatment from ED2 to ED12. Course of P. chabaudi AS infection.

Nitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil–propofol anaesthesia in humans G. Echevarría, F. Elgueta, C.

Up‐ or down‐regulation of microRNAs (miRNAs) in sensory neurons of the dorsal root ganglia (DRG) in a model of bone metastases pain A.Increase in frequency.

The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high-frequency transcutaneous electric nerve.

In vitro and in vivo validation of Clcn3 as a miR‐1a‐3p target gene and its functional contribution to tumor‐induced mechanical hypersensitivity in the.

Fig. 1 SDPS induces deficits in rat spatial memory that are reversed by imipramine. SDPS induces deficits in rat spatial memory that are reversed by imipramine.

Fig. 1 MT-2 ameliorates asthmatic pulmonary resistance.

A Novel Analgesic Isolated from a Traditional Chinese Medicine

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Volume 115, Issue 2, Pages (August 1998)

Fig. 4. Perampanel ameliorates behavioral deficits in mice expressing the Thorase variants. Perampanel ameliorates behavioral deficits in mice expressing.

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

Adult neurogenesis ablation in the vDG but not in the dDG blocked the analgesic effect of EE-VEx in chronic inflammatory pain. Adult neurogenesis ablation.

Fig. 6 Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing mice. Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing.

Volume 18, Issue 5, Pages (January 2017)

N.A. Manering, T. Reuter, H. Ihmsen, D.C. Yeomans, A. Tzabazis

Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour F.S. Hasnie,

Comment on “Multiple repressive mechanisms in the hippocampus during memory formation” by Rebecca S. Mathew, Hillary Mullan, Jan Krzysztof Blusztajn, and.

Fig. 4. Local application of FR provides prolonged protection against Gq-dependent airway constriction in normal and OVA-sensitized mice in vivo. Local.

MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical.

β-Glucans do not modulate epithelial IL-33 or AHR.

Performance of chronic METH-treated rats in the gambling test under the double-reward condition. Performance of chronic METH-treated rats in the gambling.

Fig. 2 Social transfer of alcohol withdrawal–induced mechanical sensitivity to nearby water-drinking controls. Social transfer of alcohol withdrawal–induced.

Fig. 4 The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling. The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling.

Fig. 3 Sortilin deletion unmasks NTSR2 signaling.

Influence on chronic morphine on pain.

Fig. 1 KCC2 down-regulation is prevented in sortilin-deficient mice.

Fig. 1. MSCs undergo in vivo apoptosis after infusion without affecting immunosuppression. MSCs undergo in vivo apoptosis after infusion without affecting.

Fig. 1. Iontophoretic devices used for the delivery of cytotoxic agents to solid tumors. Iontophoretic devices used for the delivery of cytotoxic agents.

Fig. 4 Demonstration of optogenetic and microfluidic capabilities of the wireless, battery-free optofluidic nerve cuff system. Demonstration of optogenetic.

Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.

Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.

Effect of cocaine on locomotion.

Treating ischemia via recruitment of antigen-specific T cells

Fig. 3 Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. Treating vaccinated.

Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice.

Referred visceral hyperalgesia in wild-type (+/+) and Nav1

Fig. 2 Images of complex structures formed via sequential folding.

by Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Xudong Zhang, Anna R

MET-1 increases DRG neuron K+ currents.

NicA2-J1 prevents nicotine addiction–like behavior during withdrawal

Intra-amygdala MPEP is analgesic during bladder distention.

Cannabidiol inhibits paclitaxel‐induced neuropathic pain through 5‐HT1A receptors without diminishing nervous system function or chemotherapy efficacy.

Fig. 3. Effects of RP on SPS-CF stress-induced memory impairment of spatial memory. (A) Latency to find hidden platform in Morris water maze during 5 daily.

by Cathryn A. Manduca, Ellen R. Iverson, Michael Luxenberg, R

Fig. 1. The HCN channel blocker ivabradine (IVA) is analgesic in a mouse model of type 1 diabetes. The HCN channel blocker ivabradine (IVA) is analgesic.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.

Fig. 3. Human liver tissue seed graft function.

Neutralization of CSF1 and Ad5-HRG treatment.

Fig. 1 Social transfer of CFA and morphine withdrawal–induced pain.

Candesartan diminishes SynO-mediated morphofunctional responses in microglia. Candesartan diminishes SynO-mediated morphofunctional responses in microglia.

Fig. 7 FAE-20 increases hippocampal excitability and leads to more stable contextual fear memory in mice. FAE-20 increases hippocampal excitability and.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Subodh Verma et al. BTS 2018;3:

Fig. 4 In vivo evaluation of insulin complex for type 1 diabetic mice treatment. In vivo evaluation of insulin complex for type 1 diabetic mice treatment.

Fig. 6 NicA2-J1 prevents nicotine- and stress-induced reinstatement after extinguished nicotine intake. NicA2-J1 prevents nicotine- and stress-induced.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Presentation transcript:

Fig. 3 Social transfer occurs via alcohol withdrawal–specific olfactory cues, and this state leads to chemical and thermal hyperalgesia. Social transfer occurs via alcohol withdrawal–specific olfactory cues, and this state leads to chemical and thermal hyperalgesia. (A) Experimental timeline for (B) to (G). Von Frey (thick orange arrows); ethanol [EtOH, 3 to 10% (v/v)]. (B) When a group of mice housed in a separate room (H2O/Olfactory-WD; n = 8) was exposed to bedding from the cages of H2O/Co-Housed mice (n = 9) and EtOH/Co-Housed/WD mice (n = 8), they demonstrated significant decreases in mechanical thresholds within 24 hours. Mice exposed to bedding from naïve water-drinking mice maintained baseline levels of sensitivity (H2O/Olfactory-CTRL; n = 16). H2O/Co-Housed and EtOH/Co-Housed/WD mice began the experiment 1 day before H2O/Olfactory-WD mice, and transfer of bedding is represented by thin blue arrows. Repeated-measures ANOVA revealed a significant effect of treatment (F3,37 = 7.3, P = 0.0006) and test session (F2,74 = 26.7, P < 0.0001), as well as a significant interaction (F6,74 = 3.3, P = 0.0068). (C) The mechanical hypersensitivity in groups of mice from the olfactory experiment (H2O/Co-Housed, EtOH/Co-Housed, and H2O/Olfactory-WD) and the no withdrawal experiment (Fig. 1D) manifests as hyperalgesia following a low concentration (1.5%) of formalin (black syringe) in a pattern that was significant during the second phase of the formalin test according to one-way ANOVA (F4,30 = 10.19, P <.0001). (D) There were no significant differences in the percent of time spent on closed or open arms for any group (H2O/Separate, n = 9; EtOH/Co-Housed, n = 9; and H2O/Co-Housed, n = 9) according to ANOVA (P > 0.05). (E) H2O/Co-Housed mice (n = 14) and EtOH/Co-Housed/WD mice (n = 14) were treated with diazepam (Diaz; 1.0 mg/kg; maroon syringe; n = 7) or vehicle (Veh; n = 7) 20 min before the second von Frey test. Diazepam had no effect on mechanical thresholds in any group, according to ANOVA (P > 0.05). (F) H2O/Co-Housed and EtOH/Co-Housed/WD were treated with metyrapone (Met; 50.0 mg/kg; maroon syringe) or vehicle (Veh) 20 min before the second von Frey test. Metyrapone had no effect on mechanical thresholds in any group (EtOH/Co-Housed, n = 5; H2O/Co-Housed, n = 7) compared to vehicle (EtOH/Co-Housed, n = 4; H2O /Co-Housed, n = 8), according to ANOVA (P > 0.05). (G) Acoustic startle responses did not differ between Co-Housed (n = 8/group) and Separate (n = 8) mice according to repeated-measures ANOVA (P > 0.05). Significant changes (P < 0.05) from baseline according to Bonferroni’s post hoc analyses are represented by #. Significant differences compared to control (P < 0.05) are represented by *. Nonsignificant differences are represented by NS. Mean basal responses of all groups are represented by a dotted line. Monique L. Smith et al. Sci Adv 2016;2:e1600855 Copyright © 2016, The Authors