Cartoon model for the increased p-HLA display engendered by peptide splicing. Cartoon model for the increased p-HLA display engendered by peptide splicing.

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Presentation transcript:

Cartoon model for the increased p-HLA display engendered by peptide splicing. Cartoon model for the increased p-HLA display engendered by peptide splicing. Although conventional, linear peptides allow sampling of (for any given HLA allele) limited regions of the proteome, we propose that the combined actions of cis- and trans-splicing enable a greater proportion of the cellular proteome to be displayed for scrutiny by T cells. Pouya Faridi et al. Sci. Immunol. 2018;3:eaar3947 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works