Motor Fluctuations in PD

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Presentation transcript:

Motor Fluctuations in PD

Motor Fluctuations of PD Symptoms Levodopa

Prevalence of Treatment Complications

Case 1: 57-Year-Old Man History

Case 1: 57-Year-Old Man History (cont)

Classification of Levodopa-Related Motor Fluctuations in PD

Risk Factors for Motor Fluctuation

Levodopa: Mechanisms That Contribute to Motor Fluctuation

Levodopa: Mechanisms That Contribute to Motor Fluctuation (cont)

Strategies for Patients Experiencing OFF Periods

Options for Case Patient 1 FDA-Approved Adjunctive Therapies

Surgical Options

Effective Patient Management

Case 1: Concluding Remarks

Case 2: 77-Year-Old Man

Case 2: 77-Year-Old Man (cont)

Components of a Thorough Assessment

Progression of PD Introduction of LID

Classifications of LID Time of Symptom Onset

When to Switch Therapy?

Patient and Caregiver Considerations

Pathogenesis of LID Pre- and Post-Synaptic Mechanisms

Case 2: Revisited

Case 2: Revisited (cont)

Orthostatic Hypotension

Concluding Remarks

Abbreviations