Mast cell–associated alveolar inflammation in patients with atopic uncontrolled asthma Cecilia K. Andersson, PhD, Anders Bergqvist, MSc, Michiko Mori,

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Mast cell–associated alveolar inflammation in patients with atopic uncontrolled asthma Cecilia K. Andersson, PhD, Anders Bergqvist, MSc, Michiko Mori, MSc, Thais Mauad, MD, PhD, Leif Bjermer, MD, PhD, Jonas S. Erjefält, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 4, Pages 905-912.e7 (April 2011) DOI: 10.1016/j.jaci.2011.01.022 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 MCT and MCTC in central airways (A and C) and alveolar parenchyma (B and D) in uncontrolled asthma compared with healthy controls. E, Central airways; F, alveolar; representative micrographs from patients with asthma, double-stained for MCT and MCTC. Scale bar, E and F = 100 μm. Inset in E is a close-up image (×600) of neighboring MCTC and MCT cells. Horizontal bars indicate median value. Journal of Allergy and Clinical Immunology 2011 127, 905-912.e7DOI: (10.1016/j.jaci.2011.01.022) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A and B, Mast cell (MC) expression (%) of FcεRI. Representative micrographs of FcεRI+ mast cells in alveolar parenchyma from controls (C) and patients with asthma (D). E and F, mast cell–bound IgE (%). Representative micrographs of IgE+ mast cells in alveolar parenchyma from controls (G) and patients with asthma (H). Scale bar, C, D, G = 50 μm; H = 25 μm. Insets represent image (×600) of mast cells double-positive for tryptase and FcεRIα or IgE. Horizontal bars indicate median value. Significant differences are shown as ∗∗P < .01, and ∗∗∗P < .001. Journal of Allergy and Clinical Immunology 2011 127, 905-912.e7DOI: (10.1016/j.jaci.2011.01.022) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Density of mast cells expressing FcεRIα (A) and mast cell–bound IgE (B) in the alveolar parenchyma in uncontrolled asthma compared with healthy controls (Ctrl). Data are presented as boxes and whiskers. Journal of Allergy and Clinical Immunology 2011 127, 905-912.e7DOI: (10.1016/j.jaci.2011.01.022) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions