Distribution of responses to vaccine antigens in the culture-positive individual group and the control group. Distribution of responses to vaccine antigens in the culture-positive individual group and the control group. (A) PT IgG; (B) PT IgA; (C) FHA IgG; (D) FHA IgA. Visit 1, antibody values for serum obtained at the time of diagnosis; visit 2, antibody values for serum obtained approximately 1 year after diagnosis; visit 3, antibody values for serum obtained approximately 2 years after diagnosis. Box-whisker plots represent boxes for medians with 25th and 75th percentiles and whiskers for 10th and 90th percentiles. Closed circles represent outliers. The numbers in each box chart represent the probability values obtained by Student's t test. Mineo Watanabe et al. Clin. Vaccine Immunol. 2006; doi:10.1128/CVI.13.3.341-348.2006