Change in first-phase insulin response (A) and pancreas triglyceride content (B) in responders and nonresponders at baseline (hatched bars), after VLCD (checkered bars), and after 6 months of weight maintenance (striped bars). *P < 0.05 for baseline–to–post-VLCD difference; #P < 0.05 for baseline–to–month 6 difference. Change in first-phase insulin response (A) and pancreas triglyceride content (B) in responders and nonresponders at baseline (hatched bars), after VLCD (checkered bars), and after 6 months of weight maintenance (striped bars). *P < 0.05 for baseline–to–post-VLCD difference; #P < 0.05 for baseline–to–month 6 difference. Sarah Steven et al. Dia Care 2016;39:808-815 ©2016 by American Diabetes Association