Acquisition of global regulators during the evolution of streptomycetes. Acquisition of global regulators during the evolution of streptomycetes. The multilocus phylogeny on which the diagram is based was derived from a catenated set of seven conserved proteins (AtpD, DnaA, DnaG, DnaK, GyrB, RecA, and RpoB) (G. Chandra, unpublished data). Points of acquisition of global regulators are based on the presence or absence of orthologues encoded in the genomes of organisms before or after branch points. Gang Liu et al. Microbiol. Mol. Biol. Rev. 2013; doi:10.1128/MMBR.00054-12