Flow of recruitment: the screening and enrolment process for a 6-week randomised double-blind placebo-controlled feasibility trial in people with multiple.

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Figure 1 Clinical correlates of neurodegeneration in MS
Sensory neuronopathy caused by dorsal root ganglionitis showing a hypercellular cluster of lymphocytes (nodule of Nageotte) indicating active neuronophagia.
REFLEX and REFLEXION study design.
(A) This 54 year old man with the flail arm syndrome has severe wasting of the arms causing profound weakness. (A) This 54 year old man with the flail.
Figure 1 MOR103 sequential-dose trial flowchart of study population with multiple sclerosis aPatients received 2 doses of study drug before trial withdrawal.
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Baseline scores and corresponding changes to week 96 of the RAPID-axSpA trial for all CZP-treated patients included in the imaging substudy for: (A) SPARCC.
Subgroup analysis of the 17 trials comparing haloperidol and placebo in schizophrenia (outcome: response rate). Subgroup analysis of the 17 trials comparing.
(A) EEG of a 75 year old woman with adult onset myoclonic epilepsy (see text, case 1), showing generalised spike and wave and polyspike and wave discharges.
SPIRIT diagram. SPIRIT diagram. The figure details the timing of enrollment activities, intervention allocation, and assessments of outcomes over the course.
 Pseudoptosis.  Pseudoptosis. This man presented with photophobia and difficulty elevating the right side of his forehead. The photograph shows his normal.
Cortical right hemisphere brain regions that have been associated with neglect include the angular (ang) and supramarginal (smg) gyri of the inferior parietal.
An example from a carotid surgery trial showing how an intention to treat analysis is less biased than an on-treatment analysis. An example from a carotid.
The parameters in the Reference Group model fit by EPP
Difference in the risk of MACEs in patients treated with anti–IL17 agents compared with the placebo in RCTs. IL,interleukin; MACEs, major adverse cardiovascular.
MILESTONE study flow diagram
Change in APOC3 level in response to treatment with APOC3 antisense oligonucleotide ISIS Phase 2, randomised, double-blind, placebo-controlled study.
Reduction of muscle soreness after intervention, described as AUC of the difference after intervention minus before intervention for placebo and leucine.
Difference in the risk of MACEs in patients treated with anti-IL23 agents compared with the placebo in RCTs. IL, interleukin; MACEs, major adverse cardiovascular.
(A) Axial CT scan of head at presentation, showing a right occipital hypodense lesion. (A) Axial CT scan of head at presentation, showing a right occipital.
Flow chart of the NELSON lung cancer screening study.
 Schematic representation of phase cancellation and temporal dispersion in demyelination.  Schematic representation of phase cancellation and temporal.
PRISMA flow diagram for selection of RCTs from leading sports medicine journals for the publication years 2005 and 2015. PRISMA, Preferred Reporting Items.
Center 2 Time (min) to Antibiotic Administration Baseline to Final Analysis. Center 2 Time (min) to Antibiotic Administration Baseline to Final Analysis.
Flow chart of article screening and selection process.
Receiver operating characteristics curves showing discrimination between patients with dementia of the Alzheimer type (at time of diagnosis) and non-demented.
Difference in the risk of MACEs in patients treated with anti-TNF agents compared with the placebo in RCTs. MACEs, major adverse cardiovascular events;
The superior quality of MRI over CT is demonstrated in this figure.
Achievement of MDA over 144 weeks in patients initially receiving adalimumab or placebo during the double-blind period. Achievement of MDA over 144 weeks.
 Anatomical illustration of the greater superficial petrosal nerve (GSPN) (black arrowheads).  Anatomical illustration of the greater superficial petrosal.
Sample MR images obtained acutely from patients 1 to 6: axial T2 weighted (DWI in case 4) on the left, coronal FLAIR on the right of each panel. Sample.
FIM total score by study visit (ITT population).
Illustration of the volumetric measures and correspondent anatomy.
General Medical Council’s (GMC) National Training Survey results for average clinic attendance per week at 33 sites across the UK in General Medical.
Clinical overall score (COS), (A); cold detection thresholds (CDT), (B); warm detection thresholds (WDT), (C); and vibration thresholds (VT), (D) in patients.
 Heavily T2-weighted MRI obtained with high resolution, showing multiple enlarged VRS, visible as well-demarcated CSF like structures, which, dependent.
 Axial MRI of a 46 year old man with secondary progressive MS showing a large left sided periventricular lesion which is hyperintense with (A) T2 weighted.
 (A) Axial FLAIR MRI reveals multiple areas of high signal intensity (arrows) in leptomeninges.  (A) Axial FLAIR MRI reveals multiple areas of high signal.
Flow diagram of studies through the review process
 Progression of autonomic symptoms including hypohidrosis (A), faintness (B), syncope (C), constipation (D), urinary dysfunction (E), and respiratory disturbance.
18F-dopa positron emission tomography (PET) in a normal subject, a patient with idiopathic Parkinson's disease (PD), and a patient with multiple system.
 Left side: normal short latency somatosensory evoked potentials (SSEPSs) after stimulation of the median nerve (top picture) and posterior tibial nerve.
Examples of the visual rating scale for the medial and lateral temporal lobe on MR coronal images displayed conventionally with the letter on the right.
 MR examination of a patient suspected of having had a dissection of the right internal carotid artery.  MR examination of a patient suspected of having.
(A) High intensity lesions in the left dorsolateral midbrain on T2 weighted magnetic resonance imaging in case 1. (A) High intensity lesions in the left.
 Percentages represent proportion of injuries which would be added if MIP is used, in relation to original number selected by primary diagnosis methodology.
 Histograms showing periods until an improvement of one Hughes grade from onset.  Histograms showing periods until an improvement of one Hughes grade from.
Abductor sign in a patient with organic paresis and a patient with non-organic paresis. Abductor sign in a patient with organic paresis and a patient with.
[123I]-FP-CIT (DaTSCAN) images demonstrating: (top left) normal tracer uptake in the putamen and caudate nuclei; then progressively decreasing uptake in.
Typical mean functional strength (where maximum function scores 5, and minimum scores zero; arithmetic mean of several activities plotted) against serum.
(A) Kinematic features of fast and accurate right wrist flexions performed by the patient before (left part) and after alcohol intake (right part). (A)
Box plot representation of total PDSS (Parkinson’s disease sleep scale) scores obtained by patients with Parkinson’s disease (PD) and controls. Box plot.
Kaplan-Meier table analysis of patients with corticobasal degeneration after onset of symptoms; the y axis refers to proportion of patients who are alive.
(A) Patient with acute PFP on the 4th day showed an abnormal dyphagia limit of 5 ml from paretic left sided swallowing (arrows denote second swallows).
Bilateral opercular polymicrogyria.
ACR20, ACR20 and ACR70 response rates (proportions of patients meeting ACR 20, 50% or 70% improvement criteria) in patients with rheumatoid arthritis randomised.
 A reminder of the anatomy of the pons; although included to clarify the anatomical terms, a small lesion is in fact present, illustrating how easily such.
 Axial magnetic resonance imaging (MRI) of a 30 year old man with relapsing remitting multiple sclerosis (MS) showing multiple periventricular lesions:
 Differences in time remaining independent in activities of daily living (ADL) assessed by the modified Rankin scale between patients with pure autonomic.
 Box and whisker plot of the autonomic nervous testing comparing pure autonomic failure (PAF) with multiple system atrophy (MSA).  Box and whisker plot.
Standard Protocol Items: Recommendations for Interventional Trials diagram. Standard Protocol Items: Recommendations for Interventional Trials diagram.
Axial T2-weighted MRI. (A and B) Dot-like hyperintensities characteristic of enlarged perivascular spaces (EPVS) in the basal ganglia in a patient with.
Patient disposition. *n=1 patient took prohibited concomitant medication due to an adverse event and was discontinued from the study. Patient disposition.
 T2 weighted sagittal MR shows a Chiari I malformation with tonsillar ectopia (9 mm) at the cranio–cervical junction, resulting in disruption of normal.
Study design. Study design. Patients who completed the 8-week induction study and achieved clinical response-100 (decrease in Crohn's disease activity.
Flow diagram for screening, enrolment, randomisation, data collection and analysis. Flow diagram for screening, enrolment, randomisation, data collection.
ROC curve for the TYM-MCI, ACE-R and MMSE in the separation of patients with aMCI/AD from those with SMC. ACE-R, Addenbrooke’s Cognitive Examinations;
Age-adjusted prevalence of severe centrum semiovale enlarged perivascular spaces (EPVS) (>40 EPVS) in patients with strictly lobar intracerebral haemorrhage.
Box plot showing the distribution of the TYM-MCI score for patients with SMC and aMCI/AD. aMCI/AD, amnestic mild cognitive impairment or Alzheimer’s disease;
Presentation transcript:

Flow of recruitment: the screening and enrolment process for a 6-week randomised double-blind placebo-controlled feasibility trial in people with multiple sclerosis. Flow of recruitment: the screening and enrolment process for a 6-week randomised double-blind placebo-controlled feasibility trial in people with multiple sclerosis. A total of 40 people were included in the final analysis, and reasons for not receiving the allocated intervention (cocoa drink) and discontinuation are presented. Shelly Coe et al. J Neurol Neurosurg Psychiatry 2019;90:507-513 ©2019 by BMJ Publishing Group Ltd