The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers.

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The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers versus Nonsmokers Jason M. Fritz, BS, Lori D. Dwyer-Nield, PhD, Bridgette M. Russell, BS, Alvin M. Malkinson, PhD Journal of Thoracic Oncology Volume 5, Issue 2, Pages 254-257 (February 2010) DOI: 10.1097/JTO.0b013e3181c8ce04 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Incidence and nature of Kras mutations in lung tumors. Mutation incidence by codon ([mutation type]/[total no. of mutations analyzed]), the resulting amino acid substitution, and color-coded amino acid group functionality (gray = hydrophobic, red = acidic, neutral = uncharged, and blue = basic) are shown. The total number of tumors containing mutations at each codon is represented at the top of each column. A, KRAS mutation incidence in 1132 human lung adenocarcinoma (AC) from the Catalogue of Somatic Mutations in Cancer (COSMIC) database is comparable with the 129 combined smokers and never smokers mutations reported in Refs. 2, 12, and 13. B, C, Incidence of 3-methylcholanthrene (MCA)-induced Kras mutations in 16 cBy (B) and 17 A/J (C) mice is similar to those in human never smokers and smokers (current and former), respectively. aMurine lung tumors were lung adenomas or AC as defined in “Materials and Methods” section, whereas all human lesions were lung AC. KRAS mutation incidence in smokers and never smokers in the “selected studies” is adapted with permission from Clin Cancer Res. 2008; 14:5731, Table 3; Cancer Epidemiol Biomarkers Prev. 1999;8:300, Table 2; and Cancer. 2008;113:3202. Data from Wu et al. are copyright (2008) American Cancer Society, and this material is reproduced with permission from Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Journal of Thoracic Oncology 2010 5, 254-257DOI: (10.1097/JTO.0b013e3181c8ce04) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions