Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic analyses suggest that PI3K/AKT.

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Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic network analysis of the tazarotene-treated 10-hour differentially expressed genes suggested that a significant number of the differentially expressed genes connected to the PI3K/AKT pathway as a central downstream node. The shaded shapes indicated the differentially expressed genes (*P < 0.05). The different shapes assigned to each molecule that was represented in the 10-hour differentially expressed genes list, indicate the type/function of the protein as classified by the IPA analysis software (Ingenuity). Po-Lin So et al. Cancer Prev Res 2014;7:407-417 ©2014 by American Association for Cancer Research