Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse Zhixun Dou, Shelley L. Berger  Cell Metabolism  Volume 27, Issue 4, Pages 710-711 (April 2018) DOI: 10.1016/j.cmet.2018.03.009 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Therapy-Induced Senescence Can Promote Cancer Stemness and Cancer Aggressiveness In response to cancer therapy, such as chemotherapy or radiation therapy, tumors regress by cell death (apoptosis or necrosis) and senescence. Senescence is traditionally viewed as an endpoint of cancer therapy, as senescent cells are non-dividing. However, Milanovic et al. (2018) report that senescent cells can acquire features of stemness, partly through activation of Wnt. This can give rise to tumor-initiating cells (e.g., cancer stem cells), which can eventually lead to cancer relapse and metastasis. Cell Metabolism 2018 27, 710-711DOI: (10.1016/j.cmet.2018.03.009) Copyright © 2018 Elsevier Inc. Terms and Conditions