Fig. 5 Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. Effects of in vivo blockade of TLR9 on adipose.

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Fig. 5 Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. Effects of in vivo blockade of TLR9 on adipose tissue inflammation and insulin resistance in WT mice. (A) Effects of intraperitoneal injection of iODN2088 on inflammatory gene expression in WT peritoneal macrophages (n = 5 to 6). (B) Mac3 staining of epididymal fat obtained from fat-fed WT mice treated with iODN2088 or its control (Ctrl-iODN) (n = 5 to 6). Scale bar, 100 μm. (C) Effects of in vivo iODN2088 treatment on inflammatory gene expression in epididymal fat (n = 5 to 6). (D) Effects of in vivo iODN2088 treatment on the phosphorylation of IκBα in epididymal fat (n = 5 to 6). (E) Response to intraperitoneal injection of insulin (1.0 U/kg) in iODN2088-treated or Ctrl-iODN–treated mice (n = 5 to 6). (F) Effects of in vivo iODN2088 treatment on the expression of genes related to insulin sensitivity in epididymal fat (n = 5 to 6). §P = 0.08, *P < 0.05, **P < 0.01, and ***P < 0.001. All values are means ± SEM. Sachiko Nishimoto et al. Sci Adv 2016;2:e1501332 Copyright © 2016, The Authors