The rules of run chart for determining nonrandom change. The rules of run chart for determining nonrandom change. (A) Shift: six or more consecutive points lying on one side of the median. (B) Trend: five or more consecutive points either ascending or descending. (C) Run: either too few or too many crossings of the median line. (D) (see shaded areas) Astronomical point: a point on the graph that subjectively appears out of keeping with others (shaded areas). Rory Francis McQuillan et al. CJASN 2016;11:908-914 ©2016 by American Society of Nephrology