Fig. 4 Neanderthal ancestry distribution in Eurasian populations.

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Fig. 4 Neanderthal ancestry distribution in Eurasian populations. Neanderthal ancestry distribution in Eurasian populations. (A) Neanderthal allele counts in individuals from Eurasian populations, sorted by median values on 3969 LD-pruned Neanderthal tag-SNPs. CEU, Utah Residents with Northern and Western European ancestry; GBR, British in England and Scotland; FIN, Finnish in Finland; IBS, Iberian Population in Spain; TSI, Tuscans from Italy; ITN, Italians from Northern Italy; ITC, Italians from Central Italy; ITS, Italians from Southern Italy; SAR, Italians from Sardinia; CHB, Han Chinese. (B) Matrix of significances based on Wilcoxon rank sum test between pairs of populations including (lower triangular matrix) and removing (upper) outliers (see Materials and Methods and Supplementary Materials; dark blue, adjusted P < 0.05; light blue, adjusted P > 0.05). Colored squares at the sides of the heatmap refer to the populations compared, as per Fig. 4A. (C) Correlation between Neanderthal ancestry proportions and the amount of Basal Eurasian ancestry in European clusters (see Materials and Methods and the Supplementary Materials). (D and E) Neanderthal allele frequency (AF) for selected SNPs within the indicated genes: (D) high-frequency alleles in Europe and (E) North-South Europe divergent alleles. (F) Comparisons between Northern European and Italian populations (excluding Sardinia). Bars refer to comparison for reported pairs of populations; the number of NTT SNPs is reported within bars. Each section of the circos represents a tested chromosome; points refer to NTT SNPs. Colors are the same as for bars; igr, intergenic region variant. A. Raveane et al. Sci Adv 2019;5:eaaw3492 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).