IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population María Pino-Yanes, MSc,

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Presentation transcript:

IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population María Pino-Yanes, MSc, Inmaculada Sánchez-Machín, MD, José Cumplido, MD, Javier Figueroa, MD, María José Torres-Galván, PhD, Ruperto González, MD, Almudena Corrales, CLT, Orlando Acosta-Fernández, MD, José Carlos García-Robaina, MD, Teresa Carrillo, MD, Anselmo Sánchez-Palacios, MD, Jesús Villar, MD, PhD, Mariano Hernández, PhD, Carlos Flores, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 2, Pages 573-575.e10 (February 2012) DOI: 10.1016/j.jaci.2011.10.001 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 ORs and their 95% CIs for the SNPs rs1624395 and rs1370128 in the sequential addition of atopic asthma cases according to age at diagnosis. Journal of Allergy and Clinical Immunology 2012 129, 573-575.e10DOI: (10.1016/j.jaci.2011.10.001) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association P values (in log scale) of IRAK3 gene SNPs with atopic asthma diagnosed at age 22 years or less and in a meta-analysis across Europeans. An LD plot of r2 values based on resequencing data is shown for the 58 SNPs of IRAK3, as well as their relative position in the gene. Each diamond of the LD plot represents the pairwise r2 correlation between SNPs. Journal of Allergy and Clinical Immunology 2012 129, 573-575.e10DOI: (10.1016/j.jaci.2011.10.001) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions