Effect on the recall response of Nrp1 deletion before infection.

Slides:

Advertisements

Similar presentations

Figure 2. Positive selection of J15 TCR transgenic T cells specific for H60. (A) CD4 by CD8 profiles (left) of thymocytes and numbers (right) of each thymic.

Advertisements

Volume 45, Issue 2, Pages (August 2016)

Volume 27, Issue 4, Pages (October 2007)

Type 17 immunity is increased in STAT1−/− mice.

Treg and Teff cell subsets show increased TCR overlap during colitis.

B-cell differentiation associates with down-regulation of vimentin expression. B-cell differentiation associates with down-regulation of vimentin expression.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

Volume 31, Issue 2, Pages (August 2009)

Exposure to rSema4A increases Treg cell numbers in human PBMC in vitro cultures. Exposure to rSema4A increases Treg cell numbers in human PBMC in vitro.

Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation. Colonic Treg TCRs (CT2 and CT6) drive Teff cell development in inflammation.

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

DNSP16 mutation attenuates the virulence of a mouse-adapted MERS-CoV strain. dNSP16 mutation attenuates the virulence of a mouse-adapted MERS-CoV strain.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Altered cytokine production by Klrk1−/− NOD CTL

Volume 33, Issue 1, Pages (July 2010)

Ions representative of bronchial tissue (m/z 88

Volume 29, Issue 1, Pages (July 2008)

LV activation of DCs and subsequent CD8+ T cell priming are dependent on STING and cGAS but not on MyD88, TRIF, or MAVS. LV activation of DCs and subsequent.

Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo

Manders colocalization coefficient (MCC) values quantify the different levels of colocalization between TRP75 and interacting host proteins in E. chaffeensis-infected.

FLC treatment results in an increase in ploidy in a significant fraction of cells. FLC treatment results in an increase in ploidy in a significant fraction.

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses Axel Kallies, Annie Xin, Gabrielle T.

IRF4 is required for efficient Th1 CD4+ effector cell differentiation.

Volume 35, Issue 4, Pages (October 2011)

Binding competition between B2′B3 and B3 fragments of TcdB.

Volume 29, Issue 4, Pages (October 2008)

T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity Dietmar Zehn, Michael.

Cecal metabolome during C. difficile colonization and infection.

Volume 46, Issue 4, Pages (April 2017)

Matthew A. Williams, Eugene V. Ravkov, Michael J. Bevan Immunity

Development of human T-cell subsets in NSG hL-7xhIL-15 humanized mice.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

cMΦ develop into 4 subpopulations after birth.

Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.

Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.

Volume 40, Issue 2, Pages (February 2014)

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.

TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.

Figure 4 Increased susceptibility of MIF−/− CD4+ T cells to immunosuppression by Dex in EAE (A) MOG35-55 peptide-activated donor cells from wild-type (Wt)

IRF4 is required for efficient Th1 CD4+ effector cell differentiation.

Helicobacter species induce pTreg cell differentiation during homeostasis. Helicobacter species induce pTreg cell differentiation during homeostasis. (A)

NRP1-expressing macrophages accumulate in adipose tissue during DIO and regulate weight gain and glucose tolerance. NRP1-expressing macrophages accumulate.

Comparison of conventional NSG and hIL-7 expressing NSG humanized mice

B cell development in wild-type and Syk-AQL mice.

RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development. RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development.

MRP2 inhibition mitigates pulmonary burden and bacteremia following lung challenge with S. pneumoniae. MRP2 inhibition mitigates pulmonary burden and bacteremia.

CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without.

MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. PBMCs.

Distribution of signaling molecules in a section of P

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

CD25 expression predicts effector and memory differentiation.

Comparison between early-life and year 2 AMR levels.

Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune.

Deletion of Tgfbr2 in myeloid cells elevated IFN-γ production in CD8+ T cells, and systemic IFN-γ neutralization diminished metastasis inhibition in Tgfbr2MyeKO.

The CD8+ cytotoxic T-cell response in Ron TK−/− hosts in response to tumors is necessary and sufficient to block metastasis. The CD8+ cytotoxic T-cell.

Intratumoral changes in critical lymphocyte populations and numbers after NKTR-214 treatment. Intratumoral changes in critical lymphocyte populations and.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

The effect of βAR signaling on the generation of a cytotoxic CD8+ T-cell response in vivo. The effect of βAR signaling on the generation of a cytotoxic.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

DNSP16 mutant MERS-CoV infection produces minimal changes in early host responses. dNSP16 mutant MERS-CoV infection produces minimal changes in early host.

GBM cells infected in vitro with HCMV divide less often than uninfected cells do. GBM cells infected in vitro with HCMV divide less often than uninfected.

Bb monocolonization enhances Treg population in the cLP.

Primary GBM cells are permissive to HCMV in vitro.

Presentation transcript:

Effect on the recall response of Nrp1 deletion before infection. Effect on the recall response of Nrp1 deletion before infection. (A) Experimental design showing Nrp1 deletion before infection, and then adoptive transfer of memory CD8 T cells followed by infection of congenic secondary hosts. (B) Flow cytometry plots of adoptively transferred CD8 T cell populations. Plots show ORF61 tetramer+ CD8 T cell populations (left) and YFP+ populations within the tetramer+ population (right) from mice infected with FS73 (top) or FS73R (bottom). (C and D) Graphs showing expansion of YFP+ and YFP− CD8+ ORF61 tetramer+ populations from mice infected originally with either FS73 (C) or FS73R (D) after secondary exposure to WT MHV-68. Joined lines represented paired samples (YFP+ and YFP− cells from the same mouse). Data combined from 2 experiments are presented in panels C and D. **, P < 0.01. Ji Young Hwang et al. mSphere 2019; doi:10.1128/mSphere.00221-19