Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma Naomi Tsurikisawa, MD, Hiroshi Saito,

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Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma Naomi Tsurikisawa, MD, Hiroshi Saito, PhD, Takahiro Tsuburai, MD, Chiyako Oshikata, MD, Emiko Ono, MD, Hiroyuki Mitomi, MD, Kazuo Akiyama, MD Journal of Allergy and Clinical Immunology Volume 122, Issue 3, Pages 610-616 (September 2008) DOI: 10.1016/j.jaci.2008.05.040 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Percentage of CD25 positivity in CD4+ T cells in patients with CSS and CEP, respectively, at disease onset and after treatment. Median values are shown by horizontal bars. Differences between patient groups were evaluated by using the Mann–Whitney U test. †P < .01 and ∗P < .05. NS, Not significant. Journal of Allergy and Clinical Immunology 2008 122, 610-616DOI: (10.1016/j.jaci.2008.05.040) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Percentages of CD4+CD25+ T cells producing IL-5 (A), CD4+CD25+ T cells producing IL-10 (B), and CD4+CD25− T cells producing IL-2 (C) in patients with CSS or CEP at disease onset and after treatment. Median values are shown by horizontal bars. Differences between patient groups were evaluated by using the Mann–Whitney U test. †P < .01 and ∗P < .05. NS, Not significant. Journal of Allergy and Clinical Immunology 2008 122, 610-616DOI: (10.1016/j.jaci.2008.05.040) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correlation between the percentage of CD25 positivity of CD4+ T cells and the number and distribution of involved organs. Organ involvement included asthma, sinusitis, pulmonary infiltration, mononeuritis multiplex or polyneuropathy, myocardial involvement, gastrointestinal tract involvement, renal involvement, skin involvement, central nervous system involvement, arthritis, tympanitis, eye involvement, gallbladder involvement, liver involvement, and lymphadenitis, mastitis. Open circles represent patients with CSS at onset, open triangles represent patients with CSS at relapse after initial remission, and open squares represent patients with CSS at remission after treatment. A significant linear relationship was evident (r = −0.51, P < .01) for all patient groups. Journal of Allergy and Clinical Immunology 2008 122, 610-616DOI: (10.1016/j.jaci.2008.05.040) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions