Plague’s Partners in Crime

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Plague’s Partners in Crime Kimberly M. Davis, Ralph R. Isberg Immunity Volume 41, Issue 3, Pages 347-349 (September 2014) DOI: 10.1016/j.immuni.2014.09.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 After Inoculation, Infected DCs Are Recruited from the Periphery to Primary LNs via CCR7 and S1PRs, where They Produce CCL2 and Recruit Monocytes via CCR2 and S1PRs to Primary dLNs Infected monocytes transport bacteria intracellularly to secondary LNs, where they begin to replicate extracellularly and spread to the bloodstream and tissue sites. Trafficking of infected monocytes (CX3CR1+) between primary and secondary LNs via the receptor S1P1 is particularly important in disease progression. Immunity 2014 41, 347-349DOI: (10.1016/j.immuni.2014.09.003) Copyright © 2014 Elsevier Inc. Terms and Conditions