Pediatric Heart Transplantation for Congenital and Restrictive Cardiomyopathy Bari Murtuza, MD, PhD, Matthew Fenton, MD, Michael Burch, MD, Arun Gupta,

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Pediatric Heart Transplantation for Congenital and Restrictive Cardiomyopathy Bari Murtuza, MD, PhD, Matthew Fenton, MD, Michael Burch, MD, Arun Gupta, BS, Nagarajan Muthialu, FRCS, Martin J. Elliott, MD, Tain-Yen Hsia, MD, Victor T. Tsang, MD, FRCS, Martin Kostolny, MD The Annals of Thoracic Surgery Volume 95, Issue 5, Pages 1675-1684 (May 2013) DOI: 10.1016/j.athoracsur.2013.01.014 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Mechanical circulatory support in transplant recipients. (A) Extracorporeal membrane oxygenation (ECMO) in patients before and after orthotopic heart transplantation (OHT) by diagnostic group. The most notable difference is in proportion of pre-OHT support required in patients with dilatated cardiomyopathy (DCM) compared with those with congenital heart disease (CHD) and patients with restrictive cardiomyopathy (RCM). (B) Ventricular assist device (VAD) support before and after OHT by diagnostic group. As with ECMO, the DCM cohort is remarkable for its high proportion of patients requiring preoperative VAD support. (0 = no support; 1 = support before OHT; 2 = support after OHT; 3 = support before and after OHT) (CCHD = critical congenital heart disease.) The Annals of Thoracic Surgery 2013 95, 1675-1684DOI: (10.1016/j.athoracsur.2013.01.014) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Overall Kaplan-Meier survival curves for entire study cohort. (CHD = congenital heart disease; CCHD = critical congenital heart disease; DCM = dilatated cardiomyopathy; RCM = restrictive cardiomyopathy.) The Annals of Thoracic Surgery 2013 95, 1675-1684DOI: (10.1016/j.athoracsur.2013.01.014) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier survival curves in patients with congenital heart disease (CHD) with either Glenn or Fontan circulations. The Annals of Thoracic Surgery 2013 95, 1675-1684DOI: (10.1016/j.athoracsur.2013.01.014) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Kaplan-Meier survival curves according to antibody status. (A) There was significantly better survival in patients with calculated reaction frequency (CRF) values less than 50 compared with those with higher CRF values. (B) Survival analysis according to non–donor-specific antibody (NDSA) status revealed poorer survival in patients with NDSA-positive status. The Annals of Thoracic Surgery 2013 95, 1675-1684DOI: (10.1016/j.athoracsur.2013.01.014) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions