Fig. 3 TDP1 promotes OXPHOS at basal and high ATP demands.

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Fig. 3 TDP1 promotes OXPHOS at basal and high ATP demands. TDP1 promotes OXPHOS at basal and high ATP demands. (A) Doxycycline-induced cells were plated in an XF24 Seahorse cell plate, and the bioenergetic response to 1 μM oligomycin, 1 μM FCCP, and 1 μM rotenone was analyzed in a Seahorse XF Bioanalyzer. Data represent the mean OCR of three independent experiments, and error bars represent ±1 SEM. (B to D) Mitochondrial respiration was calculated by subtracting OCR after rotenone/antimycin A from basal OCR. (E to G) ATP-coupled respiration was calculated by subtracting OCR after oligomycin from basal OCR. (H to J) SRC was calculated by subtracting maximum OCR after FCCP from basal OCR. Data are the means of three independent experiments, and error bars represent ±1 SEM. Shih-Chieh Chiang et al. Sci Adv 2017;3:e1602506 Copyright © 2017, The Authors