Strategies for adoptive immunotherapy of HCMV

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Strategies for adoptive immunotherapy of HCMV Strategies for adoptive immunotherapy of HCMV. A number of strategies have been explored for adoptive immunotherapy of HCMV. These include MHC-peptide tetramer enrichment of HCMV-specific T cells or in vitro stimulation of T cells with HCMV viral lysate, recombinant viral vectors, or synthetic peptides. Strategies for adoptive immunotherapy of HCMV. A number of strategies have been explored for adoptive immunotherapy of HCMV. These include MHC-peptide tetramer enrichment of HCMV-specific T cells or in vitro stimulation of T cells with HCMV viral lysate, recombinant viral vectors, or synthetic peptides. Following enrichment or in vitro expansion, these cells are adoptively transferred into immunocompromised individuals either as a prophylactic or therapeutic treatment. These strategies have been reported previously (47, 66, 173, 194, 216, 217, 276). PE, phycoerythrin; PBMC, peripheral blood mononuclear cells. Tania Crough, and Rajiv Khanna Clin. Microbiol. Rev. 2009; doi:10.1128/CMR.00034-08