Hemostasis Alterations in Patients With Acute Aortic Dissection

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Hemostasis Alterations in Patients With Acute Aortic Dissection Domenico Paparella, MD, Crescenzia Rotunno, BSc, Pietro Guida, PhD, Pietro Giorgio Malvindi, MD, Giuseppe Scrascia, MD, Micaela De Palo, MD, Emanuela de Cillis, MD, Alessandro S. Bortone, MD, PhD, Luigi de Luca Tupputi Schinosa, MD The Annals of Thoracic Surgery Volume 91, Issue 5, Pages 1364-1369 (May 2011) DOI: 10.1016/j.athoracsur.2011.01.058 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Mean values (standard error) of F1.2 (A), plasmin-antiplasmin (PAP) levels (B), and platelet factor 4 (C) in aortic dissection; T0 = before surgery; T1 = 45 minutes after cardiopulmonary bypass (CPB); T2 = before protamine administration; T3 = 30 minutes after protamine administration; T4 = 3 hours after the end of CPB; T5 = 24 hours after the end of operation. Dotted lines represent ranges of plasma biomarker concentration in normal population. Analysis of variance Friedman test was p < 0.001 for each comparison. (* p < 0.05 versus previous phase by means of sign test.) The Annals of Thoracic Surgery 2011 91, 1364-1369DOI: (10.1016/j.athoracsur.2011.01.058) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Mean values (standard error) of F1.2 (A) and plasmin-antiplasmin (PAP) levels (B) with (■) and without deep hypothermic circulatory arrest (DHCA) (□); T0 = before surgery; T1 = 45 minutes after cardiopulmonary bypass (CPB); T2 = before protamine administration; T4 = 3 hours after the end of CPB; T5 = 24 hours after the end of operation. T3 sample was not performed in coronary artery bypass grafting patients and therefore the T3 column was omitted. (* p < 0.05 DHCA versus No DHCA with the Mann-Whitney U test.) The Annals of Thoracic Surgery 2011 91, 1364-1369DOI: (10.1016/j.athoracsur.2011.01.058) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions