Common Temporal Identity Factors Regulate Neuronal Diversity in Fly Ventral Nerve Cord and Mouse Retina  Nikolaos Konstantinides, Anthony M. Rossi, Claude.

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Common Temporal Identity Factors Regulate Neuronal Diversity in Fly Ventral Nerve Cord and Mouse Retina  Nikolaos Konstantinides, Anthony M. Rossi, Claude Desplan  Neuron  Volume 85, Issue 3, Pages 447-449 (February 2015) DOI: 10.1016/j.neuron.2015.01.016 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Temporal Patterning in Mouse and Fly (A) Retinal cell types are born sequentially. Retinal progenitor cells (RPCs) first express Ikzf1 to specify early-born cell types (blue) before switching to express Casz1 to identify later-born retinal cell types (purple). Although the birth of cones (green) overlaps with other early-born cell types, Ikzf1 does not specify cone identity. In addition, Casz1 does not specify last-born Müller Glia (aqua), suggesting an additional temporal identity window. RGC, retinal ganglion cells; AC, amacrine cells; HC, horizontal cells; BC, bipolar cells; MG, Müller Glia. (B) Known temporal sequences in fly and mouse. Mattar et al. (2015) identified a regulatory interaction between Ikzf1/Hb and Casz1/Cas in mouse RPCs that is similar in Drosophila VNC neuroblasts. Neuron 2015 85, 447-449DOI: (10.1016/j.neuron.2015.01.016) Copyright © 2015 Elsevier Inc. Terms and Conditions