Utilizing MRD Assessment in Community Practice

Content Outline

Why Test MRD?

What Do Community Oncologists Need to Consider for MRD Testing?

Methods for MRD Assessment[a-d]

Are 2 MRD Tests Better Than 1?

Can We Inform Treatment Decisions Using MRD Assessment?

How to Decide on Which Test to Order

Managing Barriers to MRD Testing in the Community

MRD in CLL

MRD in CLL General Considerations

MURANO Data Post-Treatment Follow-Up

CLL14 Obinutuzumab ± Venetoclax vs Chlorambucil in Untreated CLL

MRD in Multiple Myeloma

MRD in MM General Considerations

Optimal Timing of MRD Assessment in MM Results From PRiMER

Is There a Role for Serial MRD Testing in Practice?

MRD in AML

CHRYSALIS Trial Data

ADMIRAL Trial Data

FLT3-Positive AML A Focus on MRD Negativity

MRD in ALL

BLAST Study Rationale

BLAST Study Results

Implications of Trial Data for Community Hematology Practices

Remaining Questions for MRD Testing

Concluding Remarks

Abbreviations

Abbreviations (cont)