Fig. 5. Paclitaxel promotes breast cancer cell dissemination and metastasis in a MENA-dependent manner. Paclitaxel promotes breast cancer cell dissemination.

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Fig. 5. Paclitaxel promotes breast cancer cell dissemination and metastasis in a MENA-dependent manner. Paclitaxel promotes breast cancer cell dissemination and metastasis in a MENA-dependent manner. (A) Experimental design and chemotherapy scheme. (B) Mouse models of breast carcinoma and cohort sizes. (C) Multichannel IF of IBA1, CD31, VEGF, and DAPI in MENA−/− MMTV-PyMT-CFP transplanted tumors, treated with either vehicle control (top panel) or paclitaxel (bottom panel). Arrowheads: VEGFhi/IBA1+ macrophages. Scale bar, 25 μm. (D) Perivascular IBA1+ macrophages (Mϕ) counted in 10 HPFs (absolute counts) in MENA−/− MMTV-PyMT-CFP transplanted tumors treated with paclitaxel or vehicle control. Mann-Whitney U test. (E and F) Perivascular TIE2hi/VEGFhi macrophages (Mϕ) quantified in MENA−/− MMTV-PyMT-CFP transplanted tumors, treated with paclitaxel or vehicle control. Absolute counts (E) or percentages (F) among all perivascular IBA1+ macrophages (Mϕ). Mann-Whitney U test. (G) CTCs per milliliter of blood collected from MENA+/+ and MENA−/− PyMT-CFP mice. Values normalized to the control group in each case to account for intercohort variability. Mann-Whitney U test. (H) Quantification of single cancer cell dissemination in the lungs of MENA+/+ and MENA−/− PyMT-CFP transplants, using fluorescence stereomicroscopy. Mann-Whitney U test. George S. Karagiannis et al., Sci Transl Med 2017;9:eaan0026 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works