Fig. 4 MxB intermolecular assembly interfaces and their role in the MxB assembly and HIV-1 inhibition. MxB intermolecular assembly interfaces and their.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 4 3D reconfiguration of liquid metals for electronics.

Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.

Fig. 2 Box plots of water use with lateral lengths.

Fig. 1 Pump-probe signatures of vermilion (red HgS), black HgS, and metallic Hg. Pump-probe signatures of vermilion (red HgS), black HgS, and metallic.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 4 Morphogenesis in the Ch-CNC host droplets and NP assemblies.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 6 Comparison of properties of water models.

Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 2 TRXSS data. TRXSS data. TRXSS data covering delay times from 10 ns to 10 ms for wild-type DmCry (A), for the DmCry(H378A) mutant (B), and for XlPho.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5 Structural photocycle for DmCry.

Fig. 1 Distribution of total and fake news shares.

Fig. 5 Analysis of VLPs formed from deletion CP mutants.

Fig. 3 Photon number statistics resulting from Fock state |l, S − l〉 interference. Photon number statistics resulting from Fock state |l, S − l〉 interference.

Fig. 2 2D QWs of different propagation lengths.

Fig. 2 Cas9/RecA-mediated in vivo gene correction of Pde6b.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 2 EUV TG signal. EUV TG signal. Black lines in (A), (B), and (C) are the EUV TG signals from Si3N4 membranes at LTG = 110, 85, and 28 nm, respectively,

Fig. 4 EUV TG signal from Si.

Fig. 6 Longevity and mechanical perturbation of a liquid membrane.

Fig. 6 WPS imaging of different chemical components in living cells.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 2 The sex-linked mbt proteome.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

by Pan Tao, Xiaorong Wu, and Venigalla Rao

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 2 Folding motions of the TCO with strain-softening behavior.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 4 SPICE simulation of stochasticity.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 4 Relationships between light and economic parameters.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 2 NP characterization.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 1 Structural and electrical properties of Bi2Se3/BaFe12O19.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 1 Global distribution of data.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Supraballs and films assembled from binary 219/217nm SPs/SMPs.

Fig. 2 Supraballs and films from binary SPs.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 2 Growth kinetics of borophene on silver.

Fig. 1 Schematic structure of a fluorescently labeled eGLP1-conjugated MALAT1 ASO and internalization of fluorescent eGLP1 and eGLP1-MALAT1-ASO. Schematic.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 3 TBK1 phosphorylates RAB7AS72 but not the equivalent residue in other RABs in vitro. TBK1 phosphorylates RAB7AS72 but not the equivalent residue.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

The combined signal spectra of PSD for protons and helium nuclei

Fig. 1 Overview of amber clast with synchrotron x-ray μCT image of articulated snake skeleton (DIP-S-0907). Overview of amber clast with synchrotron x-ray.

Fig. 1 B2 RNA directly inhibits transcription.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 6 Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. Schematic illustration of the.

Fig. 2 DFT calculations of stability and bandstructure of gallenene polymorphs. DFT calculations of stability and bandstructure of gallenene polymorphs.

Presentation transcript:

Fig. 4 MxB intermolecular assembly interfaces and their role in the MxB assembly and HIV-1 inhibition. MxB intermolecular assembly interfaces and their role in the MxB assembly and HIV-1 inhibition. (A) Intermolecular interfaces in an MxB oligomer: the canonical MxB dimer interface, interface 2 (black circle), and the lateral interfaces that link adjacent MxB dimers, interfaces 1 (blue circle) and 3 (red circle). The same color scheme is used as in Fig. 3F. (B) Interface 4 (magenta circles), the vertical interface between adjacent rungs. MxB dimer 7 starts the next rung in the helix, colored the same as dimer 1. (C to E) Expanded views of the intermolecular interfaces: interface 1 (C), interface 3 (D), and interface 4 (E). Specific residues at the interfaces are labeled, along with the secondary structures. Underlined amino acids were subjected to mutational analysis. (F) Effects of interface mutations on the MxB assembly: E285K (interface 4), F420D (interface 1), F495D, and R449D (interface 3). Negatively stained images of purified interface mutant proteins under helical assembly conditions are shown. Inset, wild-type MxB. Scale bar, 50 nm. (G) Effects of interface mutations on MxB anti–HIV-1 activity (top) (mean ± SD for minimally n = 3 independent experiments) and Western blot analysis of MxB protein expression (bottom). MBP-tagged wild-type (WT) MxB, which does not inhibit HIV-1, was used as a control. Frances J. D. Alvarez et al. Sci Adv 2017;3:e1701264 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).