Fig. 6 Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. Schematic illustration of the.

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Presentation transcript:

Fig. 6 Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. In the wild type (black), a hydrogen bond interaction (blue line) is formed between Asp11 and Trp97. In the N92I mutant (red), the side chain of Ile92 sterically blocks the hydrogen bond interaction (magenta circle). The loss of this hydrogen bond in the N92I mutant increases the GDP-bound ground-state energy and hence accelerates the GDP dissociation by lowering the activation energy along the GDP dissociation reaction coordinate. Yuki Toyama et al. Sci Adv 2019;5:eaax1595 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).