The neuropod cells. The neuropod cells. (Top left) Neuropod cells synapse with sensory neurons in the small intestine, as shown in a confocal microscopy.

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The neuropod cells. The neuropod cells. (Top left) Neuropod cells synapse with sensory neurons in the small intestine, as shown in a confocal microscopy image. Blue indicates all cells in villus; green indicates green fluorescent protein (GFP) in neuropod cell and sensory neurons. (Bottom left) This neural circuit is recapitulated in a coculture system between organoids and vagal neurons. Green indicates GFP in vagal neuron; red indicates tdTomato red fluorescence in neuropod cell. (Right) Neuropod cells transduce fast sensory signals from gut to brain. Scale bars, 10 µm. Melanie Maya Kaelberer et al. Science 2018;361:eaat5236 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works