Retained introns in AA and EA cases.

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Retained introns in AA and EA cases. Retained introns in AA and EA cases. A, The illustration on the left indicates the retained exons: The intron flanked by two exons (i.e., upstream and downstream exons) can be included (i.e., retained intron [IR] or intron retention) in the mature mRNA, when the splice site of these flanking exons is not correctly recognized by the spliceosome. We hypothesize that under-methylated introns have a higher probability to be retained. Numbers of included and excluded introns of expressed genes that were identified by rMATS program are shown in Supplementary Table S2. B, We found 44 statistically significant IRs (Supplementary Table S2). Thirty retained introns are commonly expressed in both AA and EA cases. Ten retained introns and four retained introns are more expressed in AA and in EA, respectively. C, The numbers represent the count of genes corresponding to the number of retained introns in the Venn diagram shown in B. Two genes have multiple retained intron events. Dongwook Kim et al. Mol Cancer Res 2018;16:461-469 ©2018 by American Association for Cancer Research