Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland.

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Presentation transcript:

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies  M.P. Larenza, M.F. Landoni, O.L. Levionnois, M. Knobloch, P.W. Kronen, R. Theurillat, U. Schatzmann, W. Thormann  British Journal of Anaesthesia  Volume 98, Issue 2, Pages 204-212 (February 2007) DOI: 10.1093/bja/ael336 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Mean and sd of PR plotted over time after R-/S-ketamine and S-ketamine administration to seven ponies anaesthetized with isoflurane in oxygen. The arrow marks the time of drug injection. British Journal of Anaesthesia 2007 98, 204-212DOI: (10.1093/bja/ael336) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 Mean and sd of MAP plotted over time after R-/S-ketamine and S-ketamine administration to seven ponies anaesthetized with isoflurane in oxygen. The arrow marks the time of drug injection. British Journal of Anaesthesia 2007 98, 204-212DOI: (10.1093/bja/ael336) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 Mean and sd of Pe′CO2 (a), VE (b), and Rf (c) plotted over time after R-/S-ketamine and S-ketamine administration to seven ponies anaesthetized with isoflurane in oxygen. The arrow marks the time of drug injection. British Journal of Anaesthesia 2007 98, 204-212DOI: (10.1093/bja/ael336) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 4 Mean and sd of plasma concentrations of (a) S-ketamine and R-ketamine and (b) S-norketamine and R-norketamine after R-/S-ketamine administration to seven ponies anaesthetized with isoflurane in oxygen. *P < 0.05 within treatment group. **P < 0.05 between the two treatment groups (comparison with data of Fig. 5a). British Journal of Anaesthesia 2007 98, 204-212DOI: (10.1093/bja/ael336) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 5 Mean (sd) plasma concentrations of (a) S-ketamine and (b) S-norketamine after S-ketamine administration to seven ponies anaesthetized with isoflurane in oxygen. **P < 0.05 between treatment groups (comparison with data of Fig. 4a). British Journal of Anaesthesia 2007 98, 204-212DOI: (10.1093/bja/ael336) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

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