DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.

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DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. HEC-1-A (A), HEC-1-B (B), and RL95-2 (C) cells plated in 24-well plates were treated with serial concentrations of DHA (12.5–50 μmol/L) for 96 hours and total viable cells were counted at indicated times. *, P < 0.05 compared with respective controls. HEC-1-A (D), HEC-1-B (E), and RL95-2 (F) cells in 6-well plates were incubated with 12.5 to 50 μmol/L of DHA and subjected to the colony formation assay. G, four-week-old female nude mice were randomized into four groups (n = 6) and injected with a suspension of HEC-1-A, or RL95-2 cells (H). The mice were then fed with normal (Con) or high dietary ratios of n-3/n-6 PUFAs. The tumor growth curve and a comparison of average tumor weight on the final day between the two groups are shown. Bars, mean ± SD for three independent experiments. *, P values compared with controls. Hang Zheng et al. Cancer Prev Res 2014;7:824-834 ©2014 by American Association for Cancer Research