In response to allergen, T cells and ILCs are equally important sources of IL-13. In response to allergen, T cells and ILCs are equally important sources.

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Presentation transcript:

In response to allergen, T cells and ILCs are equally important sources of IL-13. In response to allergen, T cells and ILCs are equally important sources of IL-13. Airway responsiveness to methacholine in (A) neonatal and (B) adult mice. (C) Pulmonary eosinophils (SiglecF+CD11clow/neg). Numbers of LinnegCD45+CD90+IL-13+ILCs and CD3+CD4+IL-13+ T cells in lungs of (D) adult and (E) neonatal mice. (F) Levels of IL-13 in the lung of mice exposed to HDM. IL-13+ ILCs and T cells in lungs of (G) adult and (H) neonatal mice exposed to ALT. (I) Levels of IL-13 in the lung of mice exposed to A. alternata (ALT). n = 6 to 8 allergen-exposed, n = 4 to 6 PBS. Data are representative of two experiments. *P < 0.05, **P < 0.01, ***P < 0.001. Sejal Saglani et al. Sci. Immunol. 2018;3:eaan4128 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works