T cell–derived IL-13 is essential for the inception of AHR.

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T cell–derived IL-13 is essential for the inception of AHR. T cell–derived IL-13 is essential for the inception of AHR. Three-day-old WT BALB/c and Cd4-cre Il-4Il13fl/fl (CD4Cre) mice were exposed to intermittent doses of HDM, A. alternata (ALT), or PBS for 2 weeks. (A) Representative flow cytometry plots of cytokine expressing (IL-5 and/or IL-13) CD3+CD4+ T cells. Airway responsiveness to methacholine in neonatal mice exposed to (B) HDM or (C) ALT. Lung eosinophils enumerated by flow cytometry in mice exposed to (D) HDM or (E) ALT. LinnegCD45+CD90+IL-13+ILCs in mice exposed to (F) HDM or (G) ALT. IL-5+ T cells to in mice exposed to (H) HDM or (I) ALT. IL-13 levels in mice exposed (J) HDM or (K) ALT. Muc5ac gene expression in mice exposed to (L) HDM or (M) ALT. n = 6 to 8 allergen-exposed, n = 4 to 6 PBS. Data are representative of at least two experiments. *P < 0.05, **P < 0.01, ***P < 0.001. Sejal Saglani et al. Sci. Immunol. 2018;3:eaan4128 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works