TERRA –A Calling Card for Telomerase

Slides:

Advertisements

Similar presentations

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

Advertisements

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation Agnieszka Tudek, Odil Porrua, Tomasz Kabzinski, Michael Lidschreiber,

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial- Mesenchymal Transition Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang,

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

E3-Independent Monoubiquitination of Ubiquitin-Binding Proteins Daniela Hoeller, Christina-Maria Hecker, Sebastian Wagner, Vladimir Rogov, Volker Dötsch,

Volume 60, Issue 2, Pages (October 2015)

Central Dogma Goes Digital

Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C

Approaching TERRA Firma: Genomic Functions of Telomeric Noncoding RNA

RNase E Finds Some sRNAs Stimulating

Boxuan Simen Zhao, Chuan He Molecular Cell

Methed-Up FOXOs Can't In-Akt-ivate

Skill Development in Graduate Education

Rémy Denzler, Markus Stoffel Molecular Cell

The Case of the Disappearing Drug Target

How To Choose a Good Scientific Problem

Triggering Selective Autophagy at the Right Place and the Right Time

P Bodies and the Control of mRNA Translation and Degradation

Dynamics under the Telomeric Bridge

Volume 46, Issue 5, Pages (June 2012)

Karin Johanna Ferrari, Elisa Lavarone, Diego Pasini Molecular Cell

lncRNA Structure: Message to the Heart

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

PAF Makes It EZ(H2) for β-Catenin Transactivation

William G. Kaelin, Peter J. Ratcliffe Molecular Cell

Eukaryotic Transcription Activation: Right on Target

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

Volume 36, Issue 2, Pages (October 2009)

RIG-I Holds the CARDs in a Game of Self versus Nonself

An Argonaute Protein Directs Nuclear Xrn2 Function

Mammalian Circadian Cogwheels Are Parts of Macromolecular Machines

“Cat’s Cradling” the 3D Genome by the Act of LncRNA Transcription

MicroRNAs and Viral Infection

A Method that Will Captivate U

New Insights into Genome Structure: Genes of a Feather Stick Together

Nuclear PI5P, Uhrf1, and the Road Not Taken

Volume 64, Issue 3, Pages (November 2016)

Boxuan Simen Zhao, Chuan He Molecular Cell

Easy Stress Relief by EZH2

Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

m6A mRNA Methylation: A New Circadian Pacesetter

Volume 44, Issue 5, Pages (December 2011)

Functional Enhancer Screening in Single Cells

Crossing the Exon Molecular Cell

Antiviral Immunity and Circular RNA: No End in Sight

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica Perez.

Astrocytes: Powering Memory

Molecular Mechanisms of Long Noncoding RNAs

A FIRE-y PAGE in the Computational Analysis of Cancer Profiles

Apollo—Taking the Lead in Telomere Protection

Kannanganattu V. Prasanth Molecular Cell

Silencing the Transcriptome's Dark Matter: Mechanisms for Suppressing Translation of Intergenic Transcripts Kellie S. Bickel, David R. Morris Molecular.

How To Survive and Thrive in the Mother-Mentor Marathon

How To Choose a Good Scientific Problem

Volume 61, Issue 2, Pages (January 2016)

Albert Tsai, Robert H. Singer, Justin Crocker Molecular Cell

Chaos Controlled: Discovery of a Powerful Amyloid Inhibitor

S-Nitrosylation at the Interface of Autophagy and Disease

Volume 25, Issue 2, Pages (January 2007)

Eric Verdin, Melanie Ott Molecular Cell

Volume 63, Issue 6, Pages (September 2016)

New Myc-anisms for DNA Replication and Tumorigenesis?

Marking Emerging β- and γδ-Selected T Cells

Presentation transcript:

TERRA –A Calling Card for Telomerase Elena Smekalova, Peter Baumann Molecular Cell Volume 51, Issue 6, Pages 703-704 (September 2013) DOI: 10.1016/j.molcel.2013.09.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 A Schematic Illustrating the Role of TERRA in Telomere Maintenance On long telomeres transcription of TERRA is inhibited by telomere-associated proteins including Rap1, Rif1, and Rif2 and transcripts are degraded by the RNA exonuclease Rat1. Telomere shortening triggers expression of TERRA, which assembles into a focus in the nuclear periphery. In early S phase TERRA serves as a seed for the formation of telomerase clusters. In late S phase preformed telomerase-TERRA clusters associate with the short telomere from which the TERRA transcripts originated. Molecular Cell 2013 51, 703-704DOI: (10.1016/j.molcel.2013.09.011) Copyright © 2013 Elsevier Inc. Terms and Conditions