A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. A schematic diagram showing the mechanism by which.

Slides:

Advertisements

Similar presentations

Hemostasis & Thrombosis: Platelet Disorders Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005.

Advertisements

HEMOSTASIS Hemostasis

Coagulation Just the basics.... Three steps Vasoconstriction Platelet plug formation Fibrin clot formation.

Lymphoma dissemination: the other face of lymphocyte homing by Steven T. Pals, David J. J. de Gorter, and Marcel Spaargaren Blood Volume 110(9):

HEMOSTASIS Primary hemostasis.

Nerves Smooth muscle Endothelium Platelets White cells eg neutrophils Red cells.

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial- induced signalling and cytokine secretion by.

Red blood cells mediate the onset of thrombosis in the ferric chloride murine model by Justin D. Barr, Anil K. Chauhan, Gilbert V. Schaeffer, Jessica K.

EBV-positive diffuse large B-cell lymphoma of the elderly by Chi Young Ok, Thomas G. Papathomas, L. Jeffrey Medeiros, and Ken H. Young Blood Volume 122(3):

Anesthes. 2012;116(4): doi: /ALN.0b013e31824b9512 Figure Legend:

Anesthes. 1998;88(6): Figure Legend:

Intercellular pathways through which hypoxia stimulates fibroblast activation Hypoxia activates G proteins (Gαior Gq), which initiate PI3K/Akt-, PLC/PKC-,

Anesthes. 1997;87(3): Figure Legend:

Regulation of platelet plug formation by phosphoinositide metabolism

Triple play of H pylori in ITP

Polyphosphates rock! A role in thrombosis?

Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation by Hua-Chen Chan, Liang-Yin.

Fledgling prognostic markers in CLL

by Dachuan Zhang, Chunliang Xu, Deepa Manwani, and Paul S. Frenette

Another Notch on the belt

by Kesheng Dai, Richard Bodnar, Michael C. Berndt, and Xiaoping Du

Juvenile Myelomonocytic Leukemia

“Radical” model of thrombosis

Angiopoietin-2 in CLL by Jan A. Burger Blood Volume 116(4):

PMNs deliver first aid to clot

by William C. Aird Blood Volume 101(10): May 15, 2003

Inherited CalDAG-GEFI deficiency

Heating is a multifunctional adjuvant that affects tumor microenvironment through several intrinsic and extrinsic mechanisms, which could enhance immunotherapy.

Figure 1 Mechanism of thrombus formation during ST-segment

An event of shear importance

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses by Caroline Lemieux, Ricardo Maliba, Judith.

Emerging roles for platelets as immune and inflammatory cells

Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease Julián panés*, D.Neil Granger‡ Gastroenterology

In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation by Bethan Psaila, James B. Bussel, Matthew.

by Jianwei Zhang, and Keith R. McCrae

Thrombosis in flowing blood

by Julia E. Geddings, and Nigel Mackman

by Walter Zumkeller, and Stefan Burdach

The Release of Soluble Factors Contributing to Endothelial Activation and Damage after Hematopoietic Stem Cell Transplantation Is Not Limited to the Allogeneic.

Lymphoma spread? Target CD47-SIRPα!

Defibrotide Prevents the Activation of Macrovascular and Microvascular Endothelia Caused by Soluble Factors Released to Blood by Autologous Hematopoietic.

Figure 1 The coagulation system

Change from baseline following beclomethasone/formoterol and placebo in a) platelet–monocyte aggregate formation, b) P-selectin expression and c) platelet.

Mechanism of CTLA-4-induced immunosuppression.

L-selectin–dependent rolling adhesion to TNF-α–stimulated HCMEC is reduced by NaClO3 but not by neuraminidase. L-selectin–dependent rolling adhesion to.

TNF-α–stimulated adhesion of HL60 cells to HCMEC is inhibited by neuraminidase but not by NaClO3 . TNF-α–stimulated adhesion of HL60 cells to HCMEC is.

Cyclooxygenase-2 in the kidney: good, BAD, or both?

Process and mechanisms of blood vessel formation.

Platelet ATP secretion in response to agonist stimulation.

Aggregation tracings of platelets lacking PLCβ2/β3.

Mechanism of PD-1/PD-L1 pathway-induced immunosuppression within the tumour microenvironment. Mechanism of PD-1/PD-L1 pathway-induced immunosuppression.

Molecular and cellular mechanisms of allergic disease

by Alyssa J. Moroi, Nicole M. Zwifelhofer, Matthew J. Riese, Debra K

Src kinases mediate TSP-1 inhibition of AC and PKA activity.

Schematic model of the mechanism of Tak1 protection of HSPC survival.

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

HUS and atypical HUS by T. Sakari Jokiranta Blood

Trousseau's syndrome: multiple definitions and multiple mechanisms

Yiannis S. Chatzizisis et al. JACC 2007;49:

Schematic view of intracellular signaling cascades triggered by receptor tyrosine kinase in Schwann cells. Schematic view of intracellular signaling cascades.

Schematic diagram of the mechanisms underlying astrocyte-mediated brain ischemic tolerance. Schematic diagram of the mechanisms underlying astrocyte-mediated.

How I treat disseminated intravascular coagulation

Multiple mechanisms in Trousseau's syndrome.

A binding relationship with thrombin

Interaction of platelet-decorated VWF strings with leukocytes and infected red blood cells in vitro. Interaction of platelet-decorated VWF strings with.

Correlation between urinary albumin excretion rate and expression of platelet surface markers, active GPIIb/IIIa, and P-selectin. Correlation between urinary.

Ticagrelor: agonising over its mechanisms of action

Myeloproliferative neoplasms and thrombosis

Cancer-associated pathways and biomarkers of venous thrombosis

Chimeric antigen receptor–modified T cells: CD19 and the road beyond

Presentation transcript:

A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. L5 promotes thrombogenesis by increasing endothelial expression of tissue factor and P-selectin, which are prone to enhance platelet adherence and activation. In addition, L5 activates platelets through the receptors LOX-1 and PAFR and enhances ADP-induced signaling. The receptor signaling through LOX-1 and PAFR mediates PI3K/PKC activation, which leads to the phosphorylation of AKT and reduces cAMP levels while promoting the release of granules. P-selectin is expressed on both the surface of platelets and ECs to increase platelet-EC interactions. Chan H et al. Blood 2013;122:3632-3641 ©2013 by American Society of Hematology