Differences in tumour cell metabolism and cytokine/chemokine expression among the three HCC subtypes. Differences in tumour cell metabolism and cytokine/chemokine.

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Differences in tumour cell metabolism and cytokine/chemokine expression among the three HCC subtypes. Differences in tumour cell metabolism and cytokine/chemokine expression among the three HCC subtypes. (A) Metabolomic analysis revealed featured alterations of TCA cycle, glycolysis, urea cycle, and nucleotide biosynthesis pathway in different HCC subtypes. (B) Hierarchical clustering of differentially expressed genes in the three HCC subtypes. (C) KEGG pathway enrichment of RNA- seq data showed significant changes in metabolism among the three HCC subtypes. Arrows indicate metabolism-related pathways. (D) Expression of important chemokines, cytokines, and other secretory biomaterials among the three HCC subtypes is shown. Data derived from RNA-seq. *P<0.05; **P< 0.01; ***P< 0.001. Qi Zhang et al. Gut doi:10.1136/gutjnl-2019-318912 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.