a) Smokers’ macrophages show a fine, golden haemosiderin cytoplasmic pigment; b) in respiratory bronchiolitis (RB), smokers’ macrophages are located in the bronchiolar lumen and peribronchiolar alveoli; in c) RB-associated interstitial lung disease and d) d... a) Smokers’ macrophages show a fine, golden haemosiderin cytoplasmic pigment; b) in respiratory bronchiolitis (RB), smokers’ macrophages are located in the bronchiolar lumen and peribronchiolar alveoli; in c) RB-associated interstitial lung disease and d) desquamative interstitial pneumonia, smokers’ macrophages progressively expand to the peripheral alveoli. Giulio Rossi et al. Eur Respir Rev 2017;26:170009 ©2017 by European Respiratory Society