Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials†   C. Remy, E. Marret,

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Presentation transcript:

Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials†   C. Remy, E. Marret, F. Bonnet  British Journal of Anaesthesia  Volume 94, Issue 4, Pages 505-513 (April 2005) DOI: 10.1093/bja/aei085 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 Flowchart of systematic research. British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effect of acetaminophen vs placebo on postoperative nausea and vomiting.426–31 British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 Effect of acetaminophen vs placebo on sedation.427–31 British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Effect of acetaminophen vs placebo on postoperative urinary retention.42628–30 British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 5 Effect of acetaminophen vs placebo on postoperative morphine consumption during the first 24 h.427–31 British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 6 l’Abbé plot of mean VAS scores 24 h after surgery for acetaminophen vs placebo in trials for which data were available: solid triangles, VAS scores were significantly (P<0.05) lower in the acetaminophen group than in the placebo group: solid squares, no significant difference in VAS scores in the acetaminophen group compared with the placebo group. M, Mimoz et al.31; S, Siddik et al.27; Sin, Sinatra et al.26; P, Peduto et al.4; Sch, Schug et al.30; F, Fletcher et al.28 British Journal of Anaesthesia 2005 94, 505-513DOI: (10.1093/bja/aei085) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

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