Lack of innate immune cell and receptor triggering by Adjuplex.

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Lack of innate immune cell and receptor triggering by Adjuplex. Lack of innate immune cell and receptor triggering by Adjuplex. (a) Bone marrow-derived dendritic cells (BMDCs) were incubated with the concentrations of Adjuplex or the PRR ligands indicated, and surface marker expression was analyzed by flow cytometry and expressed as the percentage of positively stained cells compared to isotype controls. (b) Thp1-Blue reporter cells were pulsed with the compounds shown for 24 h, and the supernatants were assayed for secreted embryonic alkaline phosphatase. Data represent the mean ± SEM. *, P < 0.05; ***, P < 0.001; n.s., not significant; OD630nm, optical density at 630 nm. Frank Wegmann et al. Clin. Vaccine Immunol. 2015; doi:10.1128/CVI.00736-14