Amino acid substitutions in SHV ESBL derivatives.

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Amino acid substitutions in SHV ESBL derivatives. Amino acid substitutions in SHV ESBL derivatives. The amino acids listed within the grey bar are those found in the structural gene of the SHV-1 β-lactamase (25). The amino acid numbering is according to the scheme of Ambler et al. (5). Substitutions found in SHV-type ESBL derivatives are shown under the amino acids of SHV-1. SHV-type variants may contain more than one amino acid substitution. ∗, SHV-11 is not an ESBL but is included in the figure as a derivative of SHV-1. Patricia A. Bradford Clin. Microbiol. Rev. 2001; doi:10.1128/CMR.14.4.933-951.2001