Fig. 4 PPM-DD–optimized ND-drug combinations.

Slides:

Advertisements

Similar presentations

Probing Bio-Nano Interactions with Templated Polymer Particles

Advertisements

The three primary ADC components that determine which cells are targeted (antibody), how the drug is released (linker/trigger), and the mechanism of action.

Cytotoxicity of MSP samples to normal and cancer cell lines.

The additive model assumes unspecific effects of equal size in both the placebo and drug arm or groups of studies or experiments. The additive model assumes.

Challenges and Opportunities in Hormone-Resistant Prostate Cancer

Network Medicine Strikes a Blow against Breast Cancer

Effects of chemotherapy and radiotherapy on spermatogenesis in humans

Fig. 4 Schematic illustration of the pH-mediated reorganization of the interchain hydrogen bond network of the PSPMA brushes. Schematic illustration of.

Fig. 1. Schematic showing the shedding of tumor DNA from head and neck cancers into the saliva or plasma. Schematic showing the shedding of tumor DNA from.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 1 meR marks on E2F1 confer genome-wide effects.

Fig. 2 Ferroelectric domains resolved in WTe2 single crystals.

Fig. 2 Solid-state NMR spectra of ceria in contact with water.

Fig. 2 Fluence-dependent emission characteristics of CH3NH3PbI3 recorded at 15 and 300 K. Fluence-dependent emission characteristics of CH3NH3PbI3 recorded.

Fig. 6 PL study showing the lower energetic states at the layer edges.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 1 Experimental apparatus used to train and test free-flying bees on their capacity to learn addition and subtraction. Experimental apparatus used.

Fig. 1 Schematic illustration of the preparation and potential application of FMSMs. Schematic illustration of the preparation and potential application.

BMS blocks functional responses in primary immune cells driven by IFNα

Drug response profiles and experimental validation.

Fig. 6 External drivers and model response.

Fig. 5 Conceptual diagram of the impact of acid deposition on calcium cycling and subsequent plant water use. Conceptual diagram of the impact of acid.

Fig. 1 Distribution of total and fake news shares.

Fig. 4 Click Chips combined with RT-ddPCR analysis can be used to monitor dynamic changes in CTC count and CTC-derived ALK/ROS1 rearrangements in patients.

The microchip-based drug delivery device and overview of study design

Fig. 2 2D QWs of different propagation lengths.

Fig. 1 Schematic illustration and atomic-scale rendering of a silica AFM tip sliding up and down a single-layer graphene step edge on an atomically flat.

Fig. 6 WPS imaging of different chemical components in living cells.

Dynamically self-assembled patterns formed by up to 40 micro-rafts

Synergistic effect of CNP and doxorubicin (DOX) on thiol oxidation.

Fig. 3 Thermal management strategies in STD systems.

Fig. 1 Automatic optimization of rMFM parameters yields stronger agreement between empirical and simulated RSFC. Automatic optimization of rMFM parameters.

HMRS integrated with a microfluidic system for multiple analyses

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 4 Experimental outputs.

Fig. 1 Boronic acid–rich dendrimer with robust efficiency in cytosolic protein delivery. Boronic acid–rich dendrimer with robust efficiency in cytosolic.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Characteristics of ultrathin single-crystalline semiconductor films

Fig. 4 Identification of miRNA packaged within MBVs.

Fig. 1 Synthesis and characterization of Dox-CBD-SA.

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 4 Randomized benchmarking measurement.

The effect of a change in the expression level of the receptor and the binding affinity on the subcutaneous bioavailability of mAbs. The effect of a change.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Fig. 5 Cells cultured in Plasmax approximate the in vivo tumor metabolome better. Cells cultured in Plasmax approximate the in vivo tumor metabolome better.

Fig. 1 WNT antagonists synergize with taxanes.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 1 Experimental strategy and elemental and morphological analysis of 3D/2D perovskite bilayer. Experimental strategy and elemental and morphological.

Fig. 6 Experimental setup and properties of the IP screen.

Fig. 7 Global change in the collective mass for wild mammals, humans, cattle, and all livestock for the years 1900–2050. Global change in the collective.

Fig. 4 Comparison of different catalyst loading methods and substrates in the cathode of a PEMEC (one is on the membrane and the other one is on the LGDL).

Fig. 1 Fractional coverage of the mapping method used in this study.

Multiplexed four- and eight-channel devices for rapid processing

Fig. 6 The combined therapeutic efficacy of N-pepABS and low dose of Dox on MDA-MB-231 xenografts. The combined therapeutic efficacy of N-pepABS and low.

Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

Experimenter gender and replicability in science

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 5 Fabrication of origami structures by two-side illuminations.

Fig. 3 Efficiency of the GDML predictor versus a model that has been trained on energies. Efficiency of the GDML predictor versus a model that has been.

Fig. 4 Single-particle contact angle measurements.

Fig. 5 Distributions of cell nuclear area values and internuclear distances in the breast tumor specimens (Figs. 3 and 4), where bin interval = 8 and n.

Fig. 1 Chemical structures of the most commonly abused opioids.

Fig. 3. Association between peak CTL019 expansion and response.

Fig. 3 The performance and reaction process of the catalytic oxidation of benzene to phenol over FeN4/GN catalysts. The performance and reaction process.

Fig. 3 Voltage-driven phase switching in a 1T-TaS2 nano-thick crystal.

Fig. 1 ETL kills 4T1 breast carcinoma cells more efficiently than ST under static conditions. ETL kills 4T1 breast carcinoma cells more efficiently than.

Fig. 1 Schematic of doxorubicin-loaded sHDL (sHDL-DOX) for chemo-immunotherapy. Schematic of doxorubicin-loaded sHDL (sHDL-DOX) for chemo-immunotherapy.

Fig. 1 Completely derived from natural wood, nanowood with hierarchically aligned cellulose nanofibrils can be used as an anisotropic super thermal insulator.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Presentation transcript:

Fig. 4 PPM-DD–optimized ND-drug combinations. PPM-DD–optimized ND-drug combinations. (A) A schematic model of the PPM experimental framework. Dox, doxorubicin; Bleo, bleomycin; Mtx, mitoxantrone; Pac, paclitaxel. (B) PPM-derived optimal ND-drug combinations (NDC) outperform a random sampling of NDCs in effective therapeutic windows of treatment of cancer cells compared to control cells. Reprinted (adapted) with permission from H. Wang et al., Mechanism-independent optimization of combinatorial nanodiamond and unmodified drug delivery using a phenotypically driven platform technology. ACS Nano (2015/02/17, 2015). Copyright 2014 American Chemical Society. Dean Ho et al. Sci Adv 2015;1:e1500439 Copyright © 2015, The Authors