The Challenge of Insulin Titration

Program Overview

Delays in Titration of Basal Insulin

Titration of Basal Insulin -- HCPs Need to Share More Information With Patients

The Benefits of Insulin Titration

The Evolution of Basal Insulins

Trial-Level Meta-Analyses of Nocturnal Hypoglycemia With Deg-100 and Gla-300

Comparing PK/PD Data

BRIGHT: Head-to-Head Comparison of Gla-300 and Deg-100

BRIGHT: Study Endpoints and Glycemic Targets

BRIGHT Results: Glycemic Control and Weight Changes

BRIGHT: Anytime (24 h) Hypoglycemia

BRIGHT: Nocturnal (00:00 to 06:00 h) Hypoglycemia

RCT Data: Implications for Clinical Practice

The Role of RCTs and RWE

The Role of RCTs and RWE (cont)

Patient-Led Titration of Basal Insulin: TAKE CONTROL

Patient-Led Titration of Basal Insulin: TAKE CONTROL (cont)

Implications of RCTs and TAKE CONTROL for Basal Insulin Titration

Other RWE for Second-Generation Basal Insulins

Basal Insulin Titration in Clinical Practice

How Clinicians Can Help Patients Take Control of Titration

Conclusions

Abbreviations

Abbreviations (cont)