Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles John L. Frattarelli,

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Presentation transcript:

Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles John L. Frattarelli, M.D., Kathleen A. Miller, B.S., Bradley T. Miller, M.D., Karen Elkind-Hirsch, M.Sc., Ph.D., Richard T. Scott, M.D., HCLD Fertility and Sterility Volume 90, Issue 1, Pages 97-103 (July 2008) DOI: 10.1016/j.fertnstert.2007.06.009 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Rates for fertilization per retrieved oocyte (Fertilization), arrested embryos on day 2 of development (Day 2 arrest), arrested embryos on day 3 of development (Day 3 arrest), development of embryos to seven or more cells on day 3 (Day 3 ≥ 7 cells), and blastocyst development (Blastocyst) by day 5 of embryo life. Rates are shown for all 1,023 cycles (overall), and rates are calculated at 5-year male age intervals. A significant decline in blastocyst development rate was noted with advancing age (P<.001). P values shown represent values for the male population comparing ≤55 years versus >55 years of age. Fertility and Sterility 2008 90, 97-103DOI: (10.1016/j.fertnstert.2007.06.009) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Cutoff points for Outcome rates (Implantation, Pregnancy, Loss [includes all losses up to delivery], Live Birth, and Blastocyst development) based on contingency table analysis. The cutoff point was most dramatic at >50 years. Although a clinically evident decrease in implantation rates was seen with males with advancing age, the results did not reach statistical significance. A statistically significant difference in loss, live birth, and blastocyst rates was noted in males >50 years of age. Fertility and Sterility 2008 90, 97-103DOI: (10.1016/j.fertnstert.2007.06.009) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Outcome rates (Implantation, Pregnancy, Loss, and Live Birth) are shown for the entire male population (overall, N = 1,023) and at 5-year male age intervals. Although a clinically evident decrease in implantation and pregnancy rates was seen with males with advancing age, the results did not reach statistical significance. A statistically significant difference in loss and live birth rates was noted in males with advancing age. P values shown represent values for the male population ≤55 years versus >55 years of age. Fertility and Sterility 2008 90, 97-103DOI: (10.1016/j.fertnstert.2007.06.009) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions