The Ribosome and TORC2: Collaborators for Cell Growth

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The Ribosome and TORC2: Collaborators for Cell Growth Xiaoduo Xie, Kun-Liang Guan Cell Volume 144, Issue 5, Pages 640-642 (March 2011) DOI: 10.1016/j.cell.2011.02.029 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Regulation of TORC2 by PI3K and Ribosome Association In response to upstream stimulation, increased phosphatidylinositol 3-kinase (PI3K) signaling activates mTORC2 (consisting of mTOR, Rictor, Sin1, and mLST8) by promoting its association with ribosomes. mTORC2 phosphorylates the C-terminal turn motif (T450) and hydrophobic motif (S473) in AKT. AKT activation also requires phosphorylation of the activation loop (T308) by PDK1. Notably, phosphorylation of the turn motif of AKT is constitutive and cotranslational, whereas phosphorylation of the hydrophobic motif is highly dependent on PI3K signaling and posttranslational. TORC2 similarly phosphorylates the turn motif and hydrophobic motif in SGK and conventional protein kinase C (García-Martínez and Alessi, 2008; Jacinto et al., 2004; Sarbassov et al., 2005). Cell 2011 144, 640-642DOI: (10.1016/j.cell.2011.02.029) Copyright © 2011 Elsevier Inc. Terms and Conditions