Neutralizing activity of mAbs isolated from plasmablasts during acute ZIKV infection in DENV-experienced donors. Neutralizing activity of mAbs isolated.

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Neutralizing activity of mAbs isolated from plasmablasts during acute ZIKV infection in DENV-experienced donors. Neutralizing activity of mAbs isolated from plasmablasts during acute ZIKV infection in DENV-experienced donors. (A) Heat map showing mAb neutralization of ZIKV-Para, DENV1, DENV2, DENV3, and DENV4 at a concentration of 1.0 μg/ml. (B) Heat map showing neutralization IC50s for selected mAbs against ZIKV-Para, DENV1, DENV2, DENV3, and DENV4. Epitope assignments are indicated on the left. (C) Neutralization IC50s for selected mAbs against ZIKV-Para. IC50 values represent the concentration of IgG required to reduce viral infectivity by 50%. Neutralization assays were performed using a live virus plaque reduction assay. N.N., non-neutralizing. Thomas F. Rogers et al. Sci. Immunol. 2017;2:eaan6809 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works